The RNF146 E3 ubiquitin ligase is required for the control of Wnt signaling and body pattern formation in Xenopus
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.08.001
Abstract: The RING finger protein Rnf146 encodes an E3 ubiquitin ligase capable of targeting poly-ADP-ribosylated substrates for proteasomal degradation. Rnf146 has been identified as a critical regulator of Axin1 and thus of Wnt/β-catenin signaling. However its… read more here.
Keywords: pattern formation; rnf146; ubiquitin ligase; formation ... See more keywords
Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122805119
Abstract: Significance Virus-induced signal adaptor (VISA)/mitochondrial antiviral signaling protein (MAVS) is an essential adaptor protein in innate immune response to RNA viruses; understanding how VISA is regulated is important for the treatment of infectious diseases. In… read more here.
Keywords: tankyrases inhibit; response; rnf146; antiviral response ... See more keywords
RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146
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DOI: 10.1172/jci90527
Abstract: Bone undergoes continuous remodeling due to balanced bone formation and resorption mediated by osteoblasts and osteoclasts, respectively. Osteoclasts arise from the macrophage lineage, and their differentiation is dependent on RANKL, a member of the TNF… read more here.
Keywords: rnf146; ubiquitin ligase; expression; ligase rnf146 ... See more keywords