Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death.
Sign Up to like & getrecommendations! Published in 2020 at "Science signaling"
DOI: 10.1126/scisignal.aax7119
Abstract: Progressive degeneration of dopaminergic neurons characterizes Parkinson's disease (PD). This neuronal loss occurs through diverse mechanisms, including a form of programmed cell death dependent on poly(ADP-ribose) polymerase-1 (PARP1) called parthanatos. Deficient activity of the kinase… read more here.
Keywords: rnf146 expression; death; akt1 creb; creb pathway ... See more keywords
Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21828
Abstract: RNF146 is an E3 ubiquitin ligase that specifically recognizes and polyubiquitinates poly (ADP-ribose) (PAR)-conjugated substrates for proteasomal degradation. RNF146 has been shown to be neuroprotective against PAR polymerase-1 (PARP1)-induced cell death during stroke. Here we… read more here.
Keywords: receptor activation; rnf146 expression; expression; estrogen receptor ... See more keywords
Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20071772
Abstract: Ring finger protein 146 (RNF146) is an E3 ubiquitin ligase whose activity prevents poly (ADP-ribose) polymerase 1 (PARP1)-dependent neurodegeneration in Parkinson’s disease (PD). Previously, we reported that rhododendrin is a chemical inducer that increases RNF146… read more here.
Keywords: receptor activation; rnf146 expression; ohda induced; rhododendrin ... See more keywords