A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00432
Abstract: Quinazoline and its derivatives have drawn much attention in the development of potential antitumor agents. Here, we synthesized a series of 1,2,3-triazole derivatives of quinazoline at the C6 position and evaluated for their cytotoxic activity… read more here.
Keywords: derivative quinazoline; rnf168; sqstm1 p62; quinazoline ... See more keywords
Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.392
Abstract: Chromatin DNA damage response (DDR) is orchestrated by the E3 ubiquitin ligase ring finger protein 168 (RNF168), resulting in ubiquitin-dependent recruitment of DDR factors and tumor suppressors breast cancer 1 (BRCA1) and p53 binding protein… read more here.
Keywords: rnf168; proteotoxic stress; cancer; instability ... See more keywords
SET8 localization to chromatin flanking DNA damage is dependent on RNF168 ubiquitin ligase
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DOI: 10.1080/15384101.2019.1690231
Abstract: ABSTRACT The DNA damage response (DDR) associated post-translational modifications recruit chromatin remodelers, signaling proteins such as 53BP1 and repair factors to chromatin flanking DNA double strand breaks (DSBs) to promote its repair. Although localization of… read more here.
Keywords: dna damage; chromatin flanking; rnf168; damage ... See more keywords
Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Innate Immunity"
DOI: 10.1159/000527624
Abstract: The correlation between ubiquitin-editing enzyme A20 and E3 ubiquitin ligase ring finger protein (RNF) 168 has been reported to be critical for repair of DNA damage. This study aimed to evaluate the potential role of… read more here.
Keywords: editing enzyme; a20; ubiquitin editing; rnf168 ... See more keywords