Circ_0004104 Accelerates the Progression of Gastric Cancer by Regulating the miR-539-3p/RNF2 Axis
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06802-5
Abstract: Circular RNA (circRNA) has been shown to be closely associated with cancer progression, including gastric cancer (GC). However, the function of circ_0004104 in GC progression has not been clarified. The purpose of this study was… read more here.
Keywords: circ 0004104; rnf2; mir 539; cancer ... See more keywords
SBDS interacts with RNF2 and is degraded through RNF2-dependent ubiquitination.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.02.014
Abstract: Shwachman-Diamond syndrome (SDS) is an autosomal recessive disorder caused by mutation in the Shwachman-Bodian-Diamond syndrome (SBDS) gene that has a variety of clinical features, including exocrine pancreatic insufficiency and hematological dysfunction. The SBDS protein is… read more here.
Keywords: rnf2 degraded; degraded rnf2; rnf2; interacts rnf2 ... See more keywords
Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/s41590-017-0003-0
Abstract: Prolonged activation of interferon–STAT1 signaling is closely related to inflammatory autoimmune disorders, and therefore the identification of negative regulators of these pathways is important. Through high-content screening of 115 mouse RING-domain E3 ligases, we identified… read more here.
Keywords: rnf2; dna; stat1; interferon ... See more keywords
Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin-Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Heart Association"
DOI: 10.1161/jaha.125.041440
Abstract: Background Doxorubicin, a broad‐spectrum chemotherapy drug, is often associated with dosage‐dependent cardiotoxicity, which results in its limited clinical application. A therapeutic dose of doxorubicin can activate cardiac ubiquitin‐proteasome system, whereas the role and potential mechanisms… read more here.
Keywords: mercaptopyruvate sulfurtransferase; oxidative stress; hydrogen sulfide; rnf2 ... See more keywords
Down-regulation of salt-inducible kinase 1 (SIK1) is mediated by RNF2 in hepatocarcinogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13673
Abstract: Our previous study reported that down-regulation of SIK1 accelerates the growth and invasion of hepatocellular carcinoma (HCC). However, the underlying mechanism leading to SIK1 down-regulation in HCC largely remains to be determined. Herein, we demonstrated… read more here.
Keywords: hcc; rnf2; expression; sik1 ... See more keywords
Clinical significance of ring finger protein 2 high expression in skin squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Letters"
DOI: 10.3892/ol.2020.11666
Abstract: Although ring finger protein 2 (RNF2) serves an important role in the occurrence, development and regulation of various types of cancer, RNF2 expression in skin squamous cell carcinoma (SCC) remains unknown. The aim of the… read more here.
Keywords: protein; rnf2; adjacent tissues; expression ... See more keywords
RNF2 Modulates Lipid Metabolism and Inflammation in Alcohol-associated Liver Disease by Interacting with USP7
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.111290
Abstract: Alcohol-associated liver disease (ALD) is a widely prevalent chronic liver disease caused by alcohol overconsumption. However, the pathogenesis of ALD is complex and has not been fully elucidated. Ring finger protein 2 (RNF2) is associated… read more here.
Keywords: rnf2; alcohol associated; liver disease; inflammation ... See more keywords