The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25664-7
Abstract: Acute myeloid leukemia (AML) remains incurable, largely due to its resistance to conventional treatments. Here, we find that increased abundance of the ubiquitin ligase RNF5 contributes to AML development and survival. High RNF5 expression in… read more here.
Keywords: rnf5; ligase rnf5; myeloid leukemia; ubiquitin ligase ... See more keywords
E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.944101
Abstract: Herpes simplex keratitis (HSK), caused by the herpes simplex virus 1 (HSV-1), is a major blinding disease in developed countries. HSV-1 can remain latent in the host for life and cannot be eradicated. The infection… read more here.
Keywords: keratitis; rnf5; sting irf3; response ... See more keywords
Targeting of Ubiquitin E3 Ligase RNF5 as a Novel Therapeutic Strategy in Neuroectodermal Tumors
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DOI: 10.3390/cancers14071802
Abstract: Simple Summary Neuroblastoma and melanoma represent two common aggressive tumors of infancy and adulthood, respectively, with the same origin and poor prognosis. Despite the aggressive treatment, advanced neuroblastoma and melanoma patients are often refractory to… read more here.
Keywords: melanoma; ubiquitin ligase; rnf5; neuroblastoma melanoma ... See more keywords