The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
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DOI: 10.1038/s41467-021-25664-7
Abstract: Acute myeloid leukemia (AML) remains incurable, largely due to its resistance to conventional treatments. Here, we find that increased abundance of the ubiquitin ligase RNF5 contributes to AML development and survival. High RNF5 expression in… read more here.
Keywords: rnf5; ligase rnf5; myeloid leukemia; ubiquitin ligase ... See more keywords
Protein and gene levels of DNAJC21 and RNF5 as drug targets for immune thrombocytopenia: optimized post-GWAS insights.
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DOI: 10.1080/16078454.2025.2580060
Abstract: ABSTRACT Objectives Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet (PLT) destruction. Its clinical manifestations are highly heterogeneous, and the unclear pathogenesis poses significant challenges for effective treatment. The limited efficacy of… read more here.
Keywords: dnajc21 rnf5; plt; immune thrombocytopenia; rnf5 ... See more keywords
Abstract 6803: RNF5-DNAJA1 axis dictates selinexor sensitivity of multiple myeloma by regulating mitochondrial function
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DOI: 10.1158/1538-7445.am2025-6803
Abstract: Selinexor is a First-in-Class XPO1 Inhibitor approved for relapsed or refractory multiple myeloma (RRMM), but the overall response rate remains unsatisfactory. The main mechanism by which Selinexor kill MM cells is to suppress the export… read more here.
Keywords: multiple myeloma; rnf5 dnaja1; dnaja1 axis; regulating mitochondrial ... See more keywords
E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.944101
Abstract: Herpes simplex keratitis (HSK), caused by the herpes simplex virus 1 (HSV-1), is a major blinding disease in developed countries. HSV-1 can remain latent in the host for life and cannot be eradicated. The infection… read more here.
Keywords: keratitis; rnf5; sting irf3; response ... See more keywords
Targeting of Ubiquitin E3 Ligase RNF5 as a Novel Therapeutic Strategy in Neuroectodermal Tumors
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DOI: 10.3390/cancers14071802
Abstract: Simple Summary Neuroblastoma and melanoma represent two common aggressive tumors of infancy and adulthood, respectively, with the same origin and poor prognosis. Despite the aggressive treatment, advanced neuroblastoma and melanoma patients are often refractory to… read more here.
Keywords: melanoma; ubiquitin ligase; rnf5; neuroblastoma melanoma ... See more keywords