RNF8 negatively regulates NF-kappaB signaling by targeting IkappaB kinase: implications for the regulation of inflammation signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.033
Abstract: Persistent or excess activation of NF-κB leads to cancer, autoimmune and inflammatory diseases. Therefore, activated NF-κB needs to be terminated after induction, which highlights the physiological significance of NF-κB-negative regulators. However, the molecular mechanisms that… read more here.
Keywords: rnf8; kinase; activation; ikk complex ... See more keywords
RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109854
Abstract: Despite the tremendous success of targeted and conventional therapies for lung cancer, therapeutic resistance is a common and major clinical challenge. RNF8 is a ubiquitin E3 ligase that plays essential roles in the DNA damage… read more here.
Keywords: rnf8; lung cancer; resistance; cancer cell ... See more keywords
Silica nanoparticles inhibiting the differentiation of round spermatid and chromatin remodeling of haploid period via MIWI in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.117446
Abstract: Researches have shown that silica nanoparticles (SiNPs) could reduce both the quantity and quality of sperm. However, the mechanism of toxicity induced by SiNPs in the male reproductive system is still unclear. In this study,… read more here.
Keywords: rnf8; chromatin remodeling; group; silica nanoparticles ... See more keywords
RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks
Sign Up to like & getrecommendations! Published in 2021 at "Oncogenesis"
DOI: 10.1038/s41389-021-00315-0
Abstract: Ubiquitination-dependent DNA damage response (DDR) signals play a critical role in the cellular choice of DNA damage repair pathways. Human DNA helicase RecQL4 participates in DNA replication and repair, and loss of RecQL4 is associated… read more here.
Keywords: rnf8; dsb; dna; dna double ... See more keywords
RNF8 depletion attenuates hepatocellular carcinoma progression by inhibiting epithelial-mesenchymal transition and enhancing drug sensitivity
Sign Up to like & getrecommendations! Published in 2023 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2023076
Abstract: Despite substantial advances that have been made in understanding the etiology of hepatocellular carcinoma (HCC), the early-stage diagnosis and treatment of advanced-stage HCC remain a major challenge. RNF8, an E3 ligase important for the DNA… read more here.
Keywords: hepatocellular carcinoma; rnf8; mesenchymal transition; hcc ... See more keywords
Direct binding of RNF8 to SUMO2/3 promotes cell survival following DNA damage.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7624
Abstract: Ring finger protein 8 (RNF8), an FHA/RING domain containing E3 ubiquitin ligase, is critical in supporting genome integrity by facilitating the assembly of multiple DNA repair proteins at DNA lesions following DNA damage. In the… read more here.
Keywords: following dna; rnf8; dna damage; sumo2 ... See more keywords
RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.44119
Abstract: DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of DNA double-strand breaks (DSB) via ubiquitin signaling. By analyzing the TCGA database and colon cancer… read more here.
Keywords: rnf8; catenin mediated; expression; colon cancer ... See more keywords