Identification of interaction domains in the pseudorabies virus ribonucleotide reductase large and small subunits.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2020.108740
Abstract: Alphaherpesviral ribonucleotide reductase (RNR) is composed of large (pUL39, RR1) and small (pUL40, RR2) subunits. This enzyme can catalyze conversion of ribonucleotide to deoxynucleotide diphosphates that are further phosphorylated into deoxynucleotide triphosphate (dNTPs). The dNTPs… read more here.
Keywords: interaction domains; pul39 pul40; rnr; interaction ... See more keywords
A single point mutation in class III ribonucleotide reductase promoter renders Pseudomonas aeruginosa PAO1 inefficient for anaerobic growth and infection
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14051-2
Abstract: Pseudomonas aeruginosa strain PAO1 has become the reference strain in many laboratories. One enzyme that is essential for its cell division is the ribonucleotide reductase (RNR) enzyme that supplies the deoxynucleotides required for DNA synthesis… read more here.
Keywords: class iii; pao1; rnr; strain ... See more keywords
Energy-Efficient Reduce-and-Rank Using Input-Adaptive Approximations
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Transactions on Very Large Scale Integration (VLSI) Systems"
DOI: 10.1109/tvlsi.2016.2586379
Abstract: Approximate computing is an emerging design paradigm that exploits the intrinsic ability of applications to produce acceptable outputs even when their computations are executed approximately. In this paper, we explore approximate computing for a key… read more here.
Keywords: quality; computation; energy; approximation ... See more keywords
Pseudomonas aeruginosa Nonphosphorylated AlgR Induces Ribonucleotide Reductase Expression under Oxidative Stress Infectious Conditions
Sign Up to like & getrecommendations! Published in 2023 at "mSystems"
DOI: 10.1128/msystems.01005-22
Abstract: The emergence of multidrug-resistant bacteria is a serious problem worldwide. Pseudomonas aeruginosa is a pathogen that causes severe infections because it can form a biofilm that protects it from immune system mechanisms such as the… read more here.
Keywords: stress; pseudomonas aeruginosa; oxidative stress; rnrs ... See more keywords
Patient demographics and MRI-based measurements predict redundant nerve roots in lumbar spinal stenosis: a retrospective database cohort comparison
Sign Up to like & getrecommendations! Published in 2018 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-018-2364-4
Abstract: BackgroundUp to 40% of patients diagnosed with lumbar spinal stenosis (LSS) show evidence of redundant nerve roots (RNR) of the cauda equina on their magnetic resonance images (MRI). The etiology of RNR is still unclear.… read more here.
Keywords: redundant nerve; lumbar spinal; spinal stenosis; rnr ... See more keywords
A rapid and sensitive assay for quantifying the activity of both aerobic and anaerobic ribonucleotide reductases acting upon any or all substrates
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269572
Abstract: Ribonucleotide reductases (RNRs) use radical-based chemistry to catalyze the conversion of all four ribonucleotides to deoxyribonucleotides. The ubiquitous nature of RNRs necessitates multiple RNR classes that differ from each other in terms of the phosphorylation… read more here.
Keywords: activity aerobic; rnrs; rnr; activity ... See more keywords
Identification of Monobenzone as a Novel Potential Anti-Acute Myeloid Leukaemia Agent That Inhibits RNR and Suppresses Tumour Growth in Mouse Xenograft Model
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194710
Abstract: Simple Summary The clinical treatment of acute myeloid leukaemia is still dominated by chemotherapy. Clinically used anti-leukaemia drugs have shortcomings such as myelosuppression, toxicity and drug resistance. Therefore, the need to develop other chemotherapeutic drugs… read more here.
Keywords: leukaemia; rrm2; rnr; acute myeloid ... See more keywords
Yeast Ribonucleotide Reductase Is a Direct Target of the Proteasome and Provides Hyper Resistance to the Carcinogen 4-NQO
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Fungi"
DOI: 10.3390/jof9030351
Abstract: Various external and internal factors damaging DNA constantly disrupt the stability of the genome. Cells use numerous dedicated DNA repair systems to detect damage and restore genomic integrity in a timely manner. Ribonucleotide reductase (RNR)… read more here.
Keywords: dna; proteasome; rnr; ribonucleotide reductase ... See more keywords