Clinical significance of anti-Ro52 (TRIM21) antibodies in adult patients with connective tissue diseases.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of internal medicine"
DOI: 10.1016/j.ejim.2021.04.020
Abstract: OBJECTIVES Clinical significance of anti-Ro52 antibodies in connective tissue diseases (CTD) is controversial. Anti-Ro52 antibodies might be associated with a more severe CTD phenotype, especially interstitial lung disease (ILD). The aims of this study were… read more here.
Keywords: ctd patients; ro52; ro52 antibodies; anti ro52 ... See more keywords
THU0614 Interstitial lung disease in patients with antisynthetase syndrome and anti-ro52 antibodies positive
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.3146
Abstract: Background Antisynthetase syndrome (ASS) is characterised by the presence of myositis, arthritis, interstitial lung disease (ILD), fever, Raynaud’s phenomenon and mechanical’s hand, in the presence of antisynthetase autoantibodies (AA), the most frequent being anti-Jo1, anti-PL7… read more here.
Keywords: ass; ro52; anti; anti ro52 ... See more keywords
AB1181 Anti-ro60 seropositivity determines epitope specificity of anti-ro52 antibodies in patients with autoimmune rheumatic and malignant diseases
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.6760
Abstract: Background Epitope mapping of anti-Ro52 antibodies (abs) has been extensively studied in patients with Sjögren’s syndrome (SjS) and systemic lupus erythematosus (SLE). Comprehensive epitope mapping in systemic sclerosis (SSc) or malignant diseases (MD), also associated… read more here.
Keywords: anti ro52; ro52 ro52; ro52pos ro60pos; ro52 ... See more keywords
AB0033 B regulatory cells positively correlate with antibodies against ss-a ro52 in systemic sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.7186
Abstract: Background We and Japanese Investigators have shown that IL-10-producing regulatory B cells (B10 cells) are decreased in systemic sclerosis (SSc).1 2 Contrary to the Japanese, we did not find a negative correlation between B10 cells… read more here.
Keywords: bregs; ro52; ssc patients; anti ro52 ... See more keywords
Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.163795
Abstract: The origin and mechanisms of autoantigen generation in systemic lupus erythematosus (SLE) are poorly understood. Here, we identified SLE neutrophils activated in vivo by IFN as a prominent source of Ro52, also known as tripartite… read more here.
Keywords: trim21; ro52 antibodies; systemic lupus; lupus erythematosus ... See more keywords
Presentations and outcomes of interstitial lung disease and the anti-Ro52 autoantibody
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Research"
DOI: 10.1186/s12931-019-1231-7
Abstract: BackgroundDistinct clinical presentations of interstitial lung disease (ILD) with the myositis-specific antibodies, including anti-synthetase antibodies, are well-recognized. However, the association between ILD and the myositis-associated antibodies, including anti-Ro52, is less established. Our objectives were to… read more here.
Keywords: ro52; disease; interstitial lung; anti ro52 ... See more keywords
Diagnostic Utility of Separate Anti-Ro60 and Anti-Ro52/TRIM21 Antibody Detection in Autoimmune Diseases
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DOI: 10.3389/fimmu.2019.00444
Abstract: Anti-SS-A antibodies are often sought for in autoimmune diseases diagnosis. Two different target proteins have actually been identified: Ro52 and Ro60. Clinical and immunological associations seem different depending on anti-Ro52 or anti-Ro60 antibodies presence. However,… read more here.
Keywords: ro52; anti ro60; ro52 ro60; anti ro52 ... See more keywords
Anti-Ro52 Autoantibodies Are Related to Chronic Graft-vs.-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
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DOI: 10.3389/fimmu.2020.01505
Abstract: Chronic graft-vs.-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous studies have shown that autoantibodies play an important role in the development of cGVHD. Anti-nuclear… read more here.
Keywords: cgvhd; ro52; graft host; anti ro52 ... See more keywords
Isolated anti-Ro52 identifies a severe subset of Sjögren’s syndrome patients
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DOI: 10.3389/fimmu.2023.1115548
Abstract: Introduction Serum autoantibodies targeting the SSA/Ro proteins are a key component of the classification criteria for the diagnosis of Sjögren’s syndrome (SS). Most patients' serum reacts with both Ro60 and Ro52 proteins. Here we compare… read more here.
Keywords: anti ro52; patients isolated; gren syndrome; syndrome patients ... See more keywords