Safety, PK/PD, and anti-tumor activity of RO6874281, an engineered variant of interleukin-2 (IL-2v) targeted to tumor-associated fibroblasts via binding to fibroblast activation protein (FAP).
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DOI: 10.1200/jco.2018.36.15_suppl.e15155
Abstract: e15155Background: High-dose (HD) IL-2 is approved for patients with melanoma and renal cell carcinoma but is associated with significant toxicity, given only in an inpatient setting. RO6874281 is a... read more here.
Keywords: tumor activity; safety anti; anti tumor; ro6874281 engineered ... See more keywords