Slit2/Robo1 signaling inhibits small‐cell lung cancer by targeting β‐catenin signaling in tumor cells and macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13289
Abstract: Small‐cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with poor patient prognosis. However, the mechanisms that regulate SCLC progression and metastasis remain undefined. Here, we show that the expression of the… read more here.
Keywords: lung cancer; slit2; tumor cells; robo1 ... See more keywords
The expression of Slit2 and Robo1 increased during retinoic acid syndrome in acute promyelocytic leukemia and impacted differentiated cell migration
Sign Up to like & getrecommendations! Published in 2022 at "Translational Oncology"
DOI: 10.1016/j.tranon.2022.101370
Abstract: Highlights • The upregulation of Robo1 and Slit2 was first found in APL patients.• The positive correlation between Robo1/Slit2 and retinoic acid syndrome was first demonstrated.• It was demonstrated for the first time that Slit2… read more here.
Keywords: acid syndrome; robo1; slit2; differentiated cell ... See more keywords
Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac070
Abstract: The Roundabout (Robo) receptors, located on growth cones of neurons, induce axon repulsion in response to the extracellular ligand Slit. The Robo family of proteins controls midline crossing of commissural neurons during development in flies.… read more here.
Keywords: human robo1; robo1; t2a gal4; variants human ... See more keywords
Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury
Sign Up to like & getrecommendations! Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000715
Abstract: Neuronal network reconstruction is a pivotal determinant for functional recovery after spinal cord injury (SCI), the process of which includes synaptogenesis. Slit2 protein has been identified as a key regulator of axon regeneration and synapse… read more here.
Keywords: sci; robo1; injury; slit2 ... See more keywords
Differential expression levels and methylation status of ROBO1 in mantle cell lymphoma and chronic lymphocytic leukaemia
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.12615
Abstract: Sir, Mantle cell lymphoma (MCL) is a mature B-cell malignancy characterized by the translocation t(11;14) (q13;q23) resulting in overexpression of the cell cycle protein cyclin D1 (CCND1). It is an extremely heterogeneous disease in terms… read more here.
Keywords: methylation; robo1; expression; blood ... See more keywords
Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/circresaha.122.321292
Abstract: BACKGROUND: Recently shown to regulate cardiac development, the secreted axon guidance molecule SLIT3 maintains its expression in the postnatal heart. Despite its known expression in the cardiovascular system after birth, SLIT3’s relevance to cardiovascular function… read more here.
Keywords: robo1; hypertrophy; slit3; pressure overload ... See more keywords
Minimal structural elements required for midline repulsive signaling and regulation of Drosophila Robo1
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0241150
Abstract: The Roundabout (Robo) family of axon guidance receptors has a conserved ectodomain arrangement of five immunoglobulin-like (Ig) domains plus three fibronectin type III (Fn) repeats. Based on the strong evolutionary conservation of this domain structure… read more here.
Keywords: robo1; repulsive signaling; midline repulsive; drosophila robo1 ... See more keywords
Pituitary stalk interruption syndrome due to novel ROBO1 mutation presenting as combined pituitary hormone deficiency and central diabetes insipidus
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2023-0541
Abstract: Abstract Objectives The genetic causes of pituitary stalk interruption syndrome (PSIS) remain elusive in 95 % of cases. The roundabout receptor-1 gene (ROBO1) plays critical roles in axonal guidance and cell migration. Recently, mutations in the… read more here.
Keywords: robo1; pituitary stalk; mutation; interruption syndrome ... See more keywords
ROBO1 Expression in Metastasizing Breast and Ovarian Cancer: SLIT2-induced Chemotaxis Requires Heparan Sulfates (Heparin)
Sign Up to like & getrecommendations! Published in 2019 at "AntiCancer Research"
DOI: 10.21873/anticanres.13237
Abstract: Background: The members of the slit homolog (SLIT) and roundabout homolog (ROBO) families have emerged as important signaling molecules in tumor metastasis. This study analyzed their role in regulating breast cancer (BC) cell motility and… read more here.
Keywords: breast; robo1; expression; ovarian cancer ... See more keywords
IMPC-based screening revealed that ROBO1 can regulate osteoporosis by inhibiting osteogenic differentiation
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2024.1450215
Abstract: Introduction The utilization of denosumab in treating osteoporosis highlights promising prospects for osteoporosis intervention guided by gene targets. While omics-based research into osteoporosis pathogenesis yields a plethora of potential gene targets for clinical transformation, identifying… read more here.
Keywords: osteoporosis; gene targets; osteogenic differentiation; robo1 ... See more keywords
Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.46042
Abstract: Proper connectivity of the nervous system requires temporal and spatial control of axon guidance signaling. As commissural axons navigate across the CNS midline, ROBO-mediated repulsion has traditionally been thought to be repressed before crossing, and… read more here.
Keywords: alternative splicing; repulsion; splicing conserved; mammalian robo1 ... See more keywords