Uncoupling axon guidance and neuronal migration in Robo3‐deficient inferior olivary neurons
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25381
Abstract: Inferior olivary (IO) neurons are born in the dorsal hindbrain and migrate tangentially toward the ventral midline. During their dorsoventral migration, IO neurons extend long leading processes that cross the midline, transform into axons, and… read more here.
Keywords: inferior olivary; olivary neurons; robo3 deficient; robo3 ... See more keywords
NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
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DOI: 10.1038/s41467-020-15211-1
Abstract: Axon pathfinding is critical for nervous system development, and it is orchestrated by molecular cues that activate receptors on the axonal growth cone. Robo family receptors bind Slit guidance cues to mediate axon repulsion. In… read more here.
Keywords: robo3; axon guidance; activation axon; family ... See more keywords
Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.154475
Abstract: Metastatic pancreatic cancer (PDAC) has a poor clinical outcome with a 5-year survival rate below 3%. Recent transcriptome profiling of PDAC biopsies has identified 2 clinically distinct subtypes — the “basal-like” (BL) subtype with poor… read more here.
Keywords: pancreatic cancer; robo3; subtype identity; guidance receptor ... See more keywords