Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08227-8
Abstract: Roundabout 4 (Robo4) is a transmembrane receptor that expresses specifically in endothelial cells. Soluble Robo4 was reported in the human plasma and mouse serum and is inhibitory towards FGF- and VEGF-induced angiogenesis. It remains unknown… read more here.
Keywords: soluble robo4; angiogenesis; robo4 constitutively; induced angiogenesis ... See more keywords
Deletion of Robo4 prevents high‐fat diet‐induced adipose artery and systemic metabolic dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Microcirculation"
DOI: 10.1111/micc.12540
Abstract: Accumulating evidence suggests the vascular endothelium plays a fundamental role in the pathophysiology of obesity by regulating the functional status of white adipose and systemic metabolism. Robo4 is expressed specifically in endothelial cells and increases… read more here.
Keywords: fat diet; robo4; deletion robo4; high fat ... See more keywords