Accurate prediction and elucidation of drug resistance based on the robust and reproducible chemoresponse communities
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31158
Abstract: Selecting the available treatment for each cancer patient from genomic context is a core goal of precision medicine, but innovative approaches with mechanism interpretation and improved performance are still highly needed. Through utilizing in vitro… read more here.
Keywords: drug; drug resistance; chemoresponse communities; robust reproducible ... See more keywords
AiZynthTrain: Robust, Reproducible, and Extensible Pipelines for Training Synthesis Prediction Models
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01486
Abstract: We introduce the AiZynthTrain Python package for training synthesis models in a robust, reproducible, and extensible way. It contains two pipelines that create a template-based one-step retrosynthesis model and a RingBreaker model that can be… read more here.
Keywords: training synthesis; aizynthtrain robust; synthesis; extensible pipelines ... See more keywords
A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00864-9
Abstract: Over the past decade, various N -methyl- d -aspartate modulators have failed in clinical trials, underscoring the challenges of developing novel rapid-acting antidepressants based solely on the receptor or regional targets of ketamine. Thus, identifying… read more here.
Keywords: robust reproducible; ketamine; connectivity; connectome fingerprint ... See more keywords
A Robust and Reproducible Method to Study Neurorepair after Stab Injury in the African Turquoise Killifish Telencephalon.
Sign Up to like & getrecommendations! Published in 2023 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot107809
Abstract: The aging population (people >60 yr old) is steadily increasing worldwide, resulting in an increased prevalence of age-related neurodegenerative diseases. Despite intensive research efforts in the past decades, there are still no therapies available to… read more here.
Keywords: turquoise killifish; injury; african turquoise; robust reproducible ... See more keywords