Design and Synthesis of Cytotoxic Water-Soluble Rocaglaol Derivatives against HEL Cells by Inhibiting Fli-1.
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DOI: 10.1021/acs.jnatprod.3c00948
Abstract: Rocaglaol, embedding a cyclopenta[b]benzofuran scaffold, was isolated mainly from the plants of Aglaia and exhibited nanomolar level antitumor activity. However, the drug-like properties of these compounds are poor. To improve the physicochemical properties of rocaglaol,… read more here.
Keywords: water; rocaglaol derivatives; hel cells; soluble derivative ... See more keywords