Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE
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DOI: 10.1136/annrheumdis-2016-209850
Abstract: Objectives Deregulated production of interleukin (IL)-17 and IL-21 contributes to the pathogenesis of autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Production of IL-17 and IL-21 can be regulated by ROCK2,… read more here.
Keywords: production; rock activity; sle; rock pathway ... See more keywords
ABL Tyrosine Kinase Inhibitors (TKIs) Are Associated with Increased Rho-Associated Kinase (ROCK) Activity That May Contribute to Vascular Toxicity in Patients with Chronic Myeloid Leukemia (CML)
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-111201
Abstract: Introduction The use of 2nd or 3rd generation ABL TKIs in patients with CML is associated with vascular toxicity, including peripheral arterial occlusive disease and cardiovascular and cerebrovascular events. However, Imatinib, a 1st generation TKI,… read more here.
Keywords: rock activity; patients receiving; leukocyte rock; tkis ... See more keywords