The effect of combined treatment with a β3AR agonist and a ROCK inhibitor on detrusor overactivity
Sign Up to like & getrecommendations! Published in 2017 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.22978
Abstract: The objective of the study was to evaluate the efficacy and safety of the combined treatment with the β3AR agonist and ROCK inhibitor in the rat model of detrusor overactivity induced by retinyl acetate instillation. read more here.
Keywords: detrusor overactivity; rock inhibitor; 3ar agonist; agonist rock ... See more keywords
Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19932-1
Abstract: Drug resistance and dose-limiting toxicities are significant barriers for treatment of multiple myeloma (MM). Bone marrow microenvironment (BMME) plays a major role in drug resistance in MM. Drug delivery with targeted nanoparticles have been shown… read more here.
Keywords: drug; multiple myeloma; rock inhibitor; efficacy ... See more keywords
Human embryonic and induced pluripotent stem cells maintain phenotype but alter their metabolism after exposure to ROCK inhibitor
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42138
Abstract: Human pluripotent stem cells (hPSCs) are adhesion-dependent cells that require cultivation in colonies to maintain growth and pluripotency. Robust differentiation protocols necessitate single cell cultures that are achieved by use of ROCK (Rho kinase) inhibitors.… read more here.
Keywords: rock inhibitor; exposure; pluripotent stem; stem ... See more keywords
Effect of Rho-associated kinase inhibitor on human corneal endothelial cell apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cataract and Refractive Surgery"
DOI: 10.1097/j.jcrs.0000000000000115
Abstract: PURPOSE To evaluate whether exposure to Rho-associated protein kinase (ROCK) inhibitor will promote human-cultured corneal endothelial cells (CECs) survival in a commercial storage medium. SETTING Edith Wolfson Medical Center, Holon, and Sheba Medical Center, Tel… read more here.
Keywords: corneal endothelial; apoptosis; rho associated; rock inhibitor ... See more keywords
Vitamin A‐coupled liposomal Rho‐kinase inhibitor ameliorates liver fibrosis without systemic adverse effects
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology Research"
DOI: 10.1111/hepr.13317
Abstract: Rho‐kinase (ROCK) inhibitor could ameliorate liver fibrosis by suppressing hepatic stellate cell (HSC) activation. However, because systemic administration of ROCK inhibitor causes serious adverse effects, we developed a drug delivery system selectively delivering ROCK inhibitor… read more here.
Keywords: inhibitor; rock inhibitor; liver fibrosis; adverse effects ... See more keywords
ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-022-00565-7
Abstract: Background Inflammation plays a major role in the pulmonary artery hypertension (PAH) and the acute lung injury (ALI) diseases. The common feature of these complications is the dysfunction of pulmonary microvascular endothelial cells (PMVECs). Fasudil,… read more here.
Keywords: rat; pulmonary microvascular; rock inhibitor; endothelial cells ... See more keywords
Early and late-onset cell migration from peripheral corneal endothelium
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0285609
Abstract: In this study we describe peripheral corneal endothelial cell migration in vitro in the absence and presence of a ROCK-inhibitor. For this study, 21 corneal endothelial graft rims, with attached trabecular meshwork (TM), were prepared… read more here.
Keywords: cell; rock inhibitor; migration; cell migration ... See more keywords
Fasudil, a ROCK inhibitor, preserves limb integrity in a mouse model of unilateral critical limb ischemia: Possible interplay of inflammatory and angiogenic signaling pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.2139/ssrn.4192500
Abstract: Peripheral arterial diseases (PAD) had a great attention owing to devastating consequences of disability and cardiovascular morbidity and mortality. Yet, current therapeutic options are limited to surgical revascularization with no effective pharmacotherapy available. Excessive activity… read more here.
Keywords: fasudil rock; limb; critical limb; rock ... See more keywords
The Effects of Different Doses of ROCK Inhibitor, Antifreeze Protein III, and Boron Added to Semen Extender on Semen Freezeability of Ankara Bucks
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27228070
Abstract: In the presented study, the effects of ROCK inhibitor Y-27632, antifreeze protein III, and boron at two different doses were investigated on the spermatological parameters of Ankara buck semen after freeze–thawing. Ejaculates were collected from… read more here.
Keywords: rock inhibitor; iii boron; boron; protein iii ... See more keywords