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Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01753
Abstract: Rho-associated coiled-coil-containing kinases (ROCKs), serine/threonine protein kinases, were initially identified as downstream targets of the small GTP-binding protein Rho. Pulmonary fibrosis (PF) is a lethal disease with limited therapeutic options and a particularly poor prognosis.…
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Keywords:
rock;
study rock;
pulmonary fibrosis;
application study ... See more keywords
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1
Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1272579
Abstract: ABSTRACT Introduction: The Rho-kinases (ROCK), ROCK1 and ROCK2, are potent, widespread biochemical modulators which have been extensively studied. Due to the involvement of ROCKs in multiple biological processes, ROCK inhibitors have pleiotropic actions and may…
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Keywords:
kinase inhibitors;
review 2014;
review;
rock inhibitors ... See more keywords
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3
Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2677
Abstract: Acute Myeloid Leukemia (AML) is a rare but catastrophic hematological cancer with a poor prognosis, high mortality, and relapse rates. Several new agents targeting specific genes or cell survival pathways have been recently approved by…
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Keywords:
rock;
aml;
rock inhibitors;
treatment ... See more keywords
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1
Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9110702
Abstract: To elucidate the additive effects of the ROCK inhibitors (ROCK-i), ripasudil (Rip) and Y27632 on bimatoprost acid (BIM-A), a prostaglandin analog (PG), on adipose tissue, two- and three-dimensional (2D or 3D) cultures of 3T3-L1 cells,…
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Keywords:
adipogenesis;
rock;
bim;
3t3 cells ... See more keywords
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0
Published in 2023 at "Journal of Current Glaucoma Practice"
DOI: 10.5005/jp-journals-10078-1396
Abstract: Abstract Aim This review summarizes current data on Rho-kinase (ROCK) inhibitors use in ocular diseases, primarily glaucoma. Background Translational research over the last decade culminating in the development of ROCK inhibitors has provided a much-needed…
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Keywords:
rock;
rho kinase;
translational research;
rock inhibitors ... See more keywords