Vitamin D attenuates myocardial ischemia–reperfusion injury by inhibiting inflammation via suppressing the RhoA/ROCK/NF‐ĸB pathway
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1797
Abstract: The aim of this study was to investigate the protective effects of vitamin D (VD) against myocardial ischemia–reperfusion (I/R) injury in hearts. An I/R injury model was induced by left coronary artery ligation in Sprague‐Dawley… read more here.
Keywords: injury; myocardial ischemia; rhoa rock; rock pathway ... See more keywords
Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2016-209850
Abstract: Objectives Deregulated production of interleukin (IL)-17 and IL-21 contributes to the pathogenesis of autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Production of IL-17 and IL-21 can be regulated by ROCK2,… read more here.
Keywords: production; rock activity; sle; rock pathway ... See more keywords
Mechanical Stretch Promotes Macrophage Polarization and Inflammation via the RhoA-ROCK/NF-κB Pathway
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DOI: 10.1155/2022/6871269
Abstract: Macrophages play an essential role in the pathogenesis of most inflammatory diseases. Recent studies have shown that mechanical load can influence macrophage function, leading to excessive and uncontrolled inflammation and even systemic damage, including cardiovascular… read more here.
Keywords: rock; rhoa rock; rhoa; rock pathway ... See more keywords
Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Pain"
DOI: 10.1177/1744806921996101
Abstract: Objectives Diabetic encephalopathy (DE) is a serious complication of diabetes mainly occurring in the elderly patients. Berberine (BBR) is an isoquinoline alkaloids extracted from Coptis chinensis that is applied in the treatment of diabetes clinically.… read more here.
Keywords: rock pathway; diabetic encephalopathy; rho rock;
Effect of Rho/ROCK pathway inhibition on metastasis-free and overall survival in biomarker selected, orthotopic, patient-derived models of pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e15759
Abstract: e15759Background: PC is a highly lethal disease which metastasises early. The sequencing efforts of the Australian Pancreatic Cancer Genome Initiative (APGI) identified ROCK-1 as a target of intere... read more here.
Keywords: rock pathway; pancreatic cancer; effect rho; cancer ... See more keywords