Hsa_circ_0041268 promotes NSCLC progress by sponging miR‐214‐5p/ROCK1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24262
Abstract: Circular RNAs hold significant regulatory functions during various tumors. However, the exact hsa_circ_0041268 roles in non‐small cell lung cancer (NSCLC) along with regulatory mechanism are unknown. In this study, RT‐qPCR was used to perceive hsa_circ_0041268… read more here.
Keywords: circ 0041268; hsa circ; mir 214; rock1 ... See more keywords
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cellular physiology"
DOI: 10.1002/jcp.28886
Abstract: Lung cancer is regarded as one of the dominant causes in cancer patients among men and women all over the world. Rho-associated coiled-coil forming protein kinase l (ROCK1) is characterized as pivotal downstream effectors of… read more here.
Keywords: cell proliferation; rock1; cancer; mir 335 ... See more keywords
Rock1 is a novel host dependency factor of human enterovirus A71: Implication as a drug target
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27975
Abstract: Human enterovirus A71 (EV‐A71) is the major causative agent of hand‐foot‐and‐mouth disease (HFMD) commonly associated with severe neurological diseases, particularly in children under 5 years of age. Several investigational therapeutic agents and vaccine candidates are… read more here.
Keywords: human enterovirus; rock1; enterovirus a71; host ... See more keywords
Sevoflurane suppresses glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2021.147543
Abstract: BACKGROUND Sevoflurane is a common inhalational anesthetic, which has been revealed to have anticancer effect in glioma. However, the mechanisms of sevoflurane in glioma progression remain largely unclear. METHODS Cell proliferation, cell cycle, apoptosis and… read more here.
Keywords: glioma; rock1; mir 633; circ 0079593 ... See more keywords
Up-regulation of Rho-associated kinase 1/2 by glucocorticoids promotes migration, invasion and metastasis of melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.09.005
Abstract: Although glucocorticoids (GCs) regulate proliferation, differentiation and apoptosis of tumor cells, their influence on metastasis of tumor cells is poorly understood. Melanoma is a type of skin cancers with high metastasis. We investigated the effect… read more here.
Keywords: melanoma; metastasis melanoma; invasion; metastasis ... See more keywords
microRNA-148a-3p enhances the effects of sevoflurane on hepatocellular carcinoma cell progression via ROCK1 repression.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109982
Abstract: BACKGROUND Sevoflurane (SEVO) inactivates the aggressiveness of hepatocellular carcinoma (HCC) cells by mediating microRNAs (miRNAs). Hence, we delved into the functional role of miR-148a-3p mediated by SEVO in HCC. METHODS Liver cells (L02) and HCC… read more here.
Keywords: hcclm3 huh7; mir 148a; rock1; cell progression ... See more keywords
Antimony enhances c-Myc stability in prostate cancer via activating CtBP2-ROCK1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2018.07.070
Abstract: Antimony, one of the heavier pnictogens, is widely used in industry, and its toxicity has become a major concern. Although previous studies suggested that antimony might be a tumorigenic risk factor in several cancers, the… read more here.
Keywords: signaling pathway; rock1; antimony; prostate cancer ... See more keywords
Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblastoma by regulating ROCK1 expression.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2021.104637
Abstract: BACKGROUND Circular RNA (circRNA) plays an important role in the malignant progression of many tumors, including retinoblastoma (RB). However, the role and regulatory mechanism of circ-E2F3 in RB have not been fully elucidated. METHODS Quantitative… read more here.
Keywords: circ e2f3; expression; rock1; mir 204 ... See more keywords
Serum ROCK1 mRNA is of great diagnostic value for glioma patients
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000015413
Abstract: Abstract The study aimed to measure the presence of rho-associated protein kinase 1 (ROCK1) mRNA in serum samples collected from glioma and investigate its diagnostic significance in glioma. The presence of ROCK1 mRNA was examined… read more here.
Keywords: glioma patients; serum rock1; rock1; rock1 mrna ... See more keywords
CIRCKLHL2 KNOCKDOWN ALLEVIATES SEPSIS-INDUCED ACUTE LUNG INJURY BY REGULATING MIR-29B-3P MEDIATED ROCK1 EXPRESSION DOWN-REGULATION
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000002034
Abstract: ABSTRACT Background: Acute lung injury (ALI) induced by sepsis is distinguished by an inflammatory progression. Herein, we investigated the action of circular RNA kelch like family member 2 (circKlhl2) in sepsis-induced ALI. Methods: The animal… read more here.
Keywords: mir 29b; sepsis; cell; rock1 ... See more keywords
Curcumin reinforces MSC‐derived exosomes in attenuating osteoarthritis via modulating the miR‐124/NF‐kB and miR‐143/ROCK1/TLR9 signalling pathways
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15714
Abstract: Curcumin treatment was reported to delay the progression of OA, but its underlying mechanism remains unclear. In this study, we aimed to investigate the molecular mechanism underlying the role of curcumin in OA treatment. Accordingly,… read more here.
Keywords: mir 143; mir; 143 mir; rock1 ... See more keywords