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   Articles with "rock2" as a keyword



Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p/ROCK2 axis

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recommendations! Published in 2020 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-020-03897-2

Abstract: Gastric cancer (GC) is a malignant tumor with high morbidity and mortality in the world. Circular RNA hsa_circHN1_005 (circ_HN1), also termed as hsa_circ_0045602, is reported as an oncogene in GC. However, the molecular mechanism of… read more here.

Keywords: circ hn1; rock2; cell; mir 302b ... See more keywords

Enhanced cutaneous Rock2 expression as a marker of Rho Kinase pathway activation in autoimmune disease and Kohlemeier-Degos disease.

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recommendations! Published in 2019 at "Annals of diagnostic pathology"

DOI: 10.1016/j.anndiagpath.2019.151414

Abstract: The small guanosine triphosphatase Rho and its target Rho kinase are involved in a heterogeneous spectrum of cellular activities, many of which are integral to cytoskeletal organization. Furthermore, the Rho kinases result in NF kappa… read more here.

Keywords: rock2; degos disease; disease; autoimmune disease ... See more keywords

Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets

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recommendations! Published in 2017 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvx071

Abstract: Aims Rho-associated coiled-coil containing kinase (ROCK)-2 is an important mediator of the actin cytoskeleton. Because changes in the actin cytoskeleton are critical for platelet function, we hypothesized that ROCK2 in platelets will play important role… read more here.

Keywords: thromboembolic stroke; rock2; mice; rock2 deficient ... See more keywords

Context-dependent signalling in platelets in vascular diseases: ROCK2 around thrombosis.

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recommendations! Published in 2017 at "Cardiovascular research"

DOI: 10.1093/cvr/cvx141

Abstract: Platelets are best known as the cellular mediator of haemostasis and thrombosis. They also possess immune and inflammatory functions that contribute to many vascular pathologies, including atherogenesis, vascular remodelling, valvar calcification, and atherothrombosis. Platelet activation… read more here.

Keywords: rock2; thrombosis; platelet activation; mice ... See more keywords

Circ_0068087 Promotes High Glucose-Induced Human Renal Tubular Cell Injury through Regulating miR-106a-5p/ROCK2 Pathway

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recommendations! Published in 2022 at "Nephron"

DOI: 10.1159/000525440

Abstract: Background: Many studies have confirmed that circular RNA (circRNA) is an important target for regulating human disease progression. This study aimed to explore the role of circ_0068087 in diabetic nephropathy (DN) progression. Methods: High glucose… read more here.

Keywords: cell; rock2; mir 106a; circ 0068087 ... See more keywords

Crucial Role of ROCK2-Mediated Phosphorylation and Upregulation of FHOD3 in the Pathogenesis of Angiotensin II–Induced Cardiac Hypertrophy

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recommendations! Published in 2017 at "Hypertension"

DOI: 10.1161/hypertensionaha.116.08662

Abstract: Cardiac hypertrophy is characterized by increased myofibrillogenesis. Angiotensin II (Ang-II) is an essential mediator of the pressure overload–induced cardiac hypertrophy in part through RhoA/ROCK (small GTPase/Rho-associated coiled-coil containing protein kinase) pathway. FHOD3 (formin homology 2… read more here.

Keywords: ang induced; cardiac hypertrophy; rock2; induced cardiac ... See more keywords

Abstract Tu067: ROCK2 Specific Inhibition Prevents Isoproterenol Induced Takotsubo Cardiomyopathy in Mice

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recommendations! Published in 2024 at "Circulation Research"

DOI: 10.1161/res.135.suppl_1.tu067

Abstract: Takotsubo Cardiomyopathy (TCM) is an acute, life-threatening condition characterized by a drop in ejection fraction (EF) and apical ballooning of the left ventricle (LV). TCM is most frequently observed in women and is associated with… read more here.

Keywords: rock2 specific; mice; inhibition; iso ... See more keywords

Regulation of oxidized LDL-induced proliferation and migration in human vascular smooth muscle cells by a novel circ_0007478/miR-638/ROCK2 ceRNA network

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recommendations! Published in 2023 at "Vascular Medicine"

DOI: 10.1177/1358863x221137617

Abstract: Background: Circular RNAs (circRNAs) have been implicated in the pathogenesis of atherosclerosis (AS) and the migration and proliferation of vascular smooth muscle cells (VSMCs) under oxidized low-density lipoprotein (ox-LDL). Here, we defined the exact action… read more here.

Keywords: mir 638; rock2; proliferation; circ 0007478 ... See more keywords

ROCK2 Polymorphism and Expression Contribute to Increased Susceptibility and Poor Prognosis in Hepatocellular Carcinoma

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recommendations! Published in 2022 at "International Journal of General Medicine"

DOI: 10.2147/ijgm.s343968

Abstract: Aim To analyze the association between ROCK2 gene polymorphism/expression and susceptibility/prognosis of hepatocellular carcinoma (HCC). Methods Peripheral venous blood from 204 hepatocellular carcinoma patients (HCC group), 242 chronic hepatitis B patients (CHB group), 215 liver… read more here.

Keywords: rock2; polymorphism; expression; rock2 gene ... See more keywords

111-OR: Vascular Endothelium-Specific ROCK2 Deficiency Inhibits the Progression of Obesity via Adipocyte Browning

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recommendations! Published in 2024 at "Diabetes"

DOI: 10.2337/db24-111-or

Abstract: Introduction and Objective: The vascular endothelium has evolved anatomical and functional network between adipocytes in adipose tissue, secreting several bioactive substances to orchestrate energy homeostasis. However, when compared with other organs, relatively little is known… read more here.

Keywords: adipocyte; none; endothelium; rock2 ... See more keywords

237-OR: Adipocyte–Endothelial Cell Cross Talk in Adipose Tissue—The Impact of Rho-Associated, Coiled-Coil–Containing Protein Kinase 2 on Insulin Resistance

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recommendations! Published in 2025 at "Diabetes"

DOI: 10.2337/db25-237-or

Abstract: Introduction and Objective: The vascular endothelium of adipose tissue plays a crucial role in regulating adipose functions. However, its role in supporting adipose tissue homeostasis under varying metabolic conditions remains unclear. This study aimed to… read more here.

Keywords: rock2; adipose tissue; insulin resistance; tissue ... See more keywords