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   Articles with "rock2" as a keyword



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Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p/ROCK2 axis

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recommendations! Published in 2020 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-020-03897-2

Abstract: Gastric cancer (GC) is a malignant tumor with high morbidity and mortality in the world. Circular RNA hsa_circHN1_005 (circ_HN1), also termed as hsa_circ_0045602, is reported as an oncogene in GC. However, the molecular mechanism of… read more here.

Keywords: circ hn1; rock2; cell; mir 302b ... See more keywords
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Enhanced cutaneous Rock2 expression as a marker of Rho Kinase pathway activation in autoimmune disease and Kohlemeier-Degos disease.

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recommendations! Published in 2019 at "Annals of diagnostic pathology"

DOI: 10.1016/j.anndiagpath.2019.151414

Abstract: The small guanosine triphosphatase Rho and its target Rho kinase are involved in a heterogeneous spectrum of cellular activities, many of which are integral to cytoskeletal organization. Furthermore, the Rho kinases result in NF kappa… read more here.

Keywords: rock2; degos disease; disease; autoimmune disease ... See more keywords
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Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets

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recommendations! Published in 2017 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvx071

Abstract: Aims Rho-associated coiled-coil containing kinase (ROCK)-2 is an important mediator of the actin cytoskeleton. Because changes in the actin cytoskeleton are critical for platelet function, we hypothesized that ROCK2 in platelets will play important role… read more here.

Keywords: thromboembolic stroke; rock2; mice; rock2 deficient ... See more keywords
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Context-dependent signalling in platelets in vascular diseases: ROCK2 around thrombosis.

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recommendations! Published in 2017 at "Cardiovascular research"

DOI: 10.1093/cvr/cvx141

Abstract: Platelets are best known as the cellular mediator of haemostasis and thrombosis. They also possess immune and inflammatory functions that contribute to many vascular pathologies, including atherogenesis, vascular remodelling, valvar calcification, and atherothrombosis. Platelet activation… read more here.

Keywords: rock2; thrombosis; platelet activation; mice ... See more keywords
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Circ_0068087 Promotes High Glucose-Induced Human Renal Tubular Cell Injury through Regulating miR-106a-5p/ROCK2 Pathway

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recommendations! Published in 2022 at "Nephron"

DOI: 10.1159/000525440

Abstract: Background: Many studies have confirmed that circular RNA (circRNA) is an important target for regulating human disease progression. This study aimed to explore the role of circ_0068087 in diabetic nephropathy (DN) progression. Methods: High glucose… read more here.

Keywords: cell; rock2; mir 106a; circ 0068087 ... See more keywords
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Crucial Role of ROCK2-Mediated Phosphorylation and Upregulation of FHOD3 in the Pathogenesis of Angiotensin II–Induced Cardiac Hypertrophy

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recommendations! Published in 2017 at "Hypertension"

DOI: 10.1161/hypertensionaha.116.08662

Abstract: Cardiac hypertrophy is characterized by increased myofibrillogenesis. Angiotensin II (Ang-II) is an essential mediator of the pressure overload–induced cardiac hypertrophy in part through RhoA/ROCK (small GTPase/Rho-associated coiled-coil containing protein kinase) pathway. FHOD3 (formin homology 2… read more here.

Keywords: ang induced; cardiac hypertrophy; rock2; induced cardiac ... See more keywords
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Regulation of oxidized LDL-induced proliferation and migration in human vascular smooth muscle cells by a novel circ_0007478/miR-638/ROCK2 ceRNA network

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recommendations! Published in 2023 at "Vascular Medicine"

DOI: 10.1177/1358863x221137617

Abstract: Background: Circular RNAs (circRNAs) have been implicated in the pathogenesis of atherosclerosis (AS) and the migration and proliferation of vascular smooth muscle cells (VSMCs) under oxidized low-density lipoprotein (ox-LDL). Here, we defined the exact action… read more here.

Keywords: mir 638; rock2; proliferation; circ 0007478 ... See more keywords
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ROCK2 Polymorphism and Expression Contribute to Increased Susceptibility and Poor Prognosis in Hepatocellular Carcinoma

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recommendations! Published in 2022 at "International Journal of General Medicine"

DOI: 10.2147/ijgm.s343968

Abstract: Aim To analyze the association between ROCK2 gene polymorphism/expression and susceptibility/prognosis of hepatocellular carcinoma (HCC). Methods Peripheral venous blood from 204 hepatocellular carcinoma patients (HCC group), 242 chronic hepatitis B patients (CHB group), 215 liver… read more here.

Keywords: rock2; polymorphism; expression; rock2 gene ... See more keywords
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Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron Excitability

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recommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2021.788039

Abstract: Intrinsic membrane excitability (IME) sets up neuronal responsiveness to synaptic drive. Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K+ channels TASK1. However, intracellular partners linking GPCRs… read more here.

Keywords: excitability; several neurotransmitters; task1; rock2 ... See more keywords
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Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer’s Disease Model

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232314788

Abstract: Alzheimer’s disease (AD) is a progressive and complex neurodegenerative disease. Acetylcholinesterase inhibitors (AChEIs) are a major class of drugs used in AD therapy. ROCK2, another promising target for AD, has been associated with the induction… read more here.

Keywords: pten akt; rock2; alzheimer disease; ache ... See more keywords

Protection against Hypoxia-Reoxygenation Injury of Hippocampal Neurons by H2S via Promoting Phosphorylation of ROCK2 at Tyr722 in Rat Model

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27144567

Abstract: The RhoA-ROCK signaling pathway is associated with the protective effects of hydrogen sulfide (H2S) against cerebral ischemia. H2S protects rat hippocampal neurons (RHNs) against hypoxia-reoxygenation (H/R) injury by promoting phosphorylation of RhoA at Ser188. However,… read more here.

Keywords: rock2; rock2 tyr722; phosphorylation rock2; injury ... See more keywords