A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies
Sign Up to like & getrecommendations! Published in 2022 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfac041
Abstract: Abstract There is growing recognition across broad sectors of the scientific community that use of genomic biomarkers has the potential to reduce the need for conventional rodent carcinogenicity studies of industrial chemicals, agrochemicals, and pharmaceuticals… read more here.
Keywords: carcinogenicity; rodent carcinogenicity; rodent; potential reduce ... See more keywords
The Antitussive Benzonatate Is Not Tumorigenic in Rodent Carcinogenicity Studies
Sign Up to like & getrecommendations! Published in 2018 at "Toxicologic Pathology"
DOI: 10.1177/0192623318789130
Abstract: Benzonatate is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Rodent carcinogenicity studies were performed in Tg.rasH2 mice and Wistar Han rats. Mice were orally gavaged benzonatate at 10, 30, 75,… read more here.
Keywords: carcinogenicity studies; day; benzonatate; rodent carcinogenicity ... See more keywords