A companion to the preclinical common data elements for rodent genetic epilepsy models. A Report of the TASK3-WG1B: Pediatric and Genetic models Working Group of the ILAE/AES Joint Translational Task Force.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia open"
DOI: 10.1002/epi4.12642
Abstract: Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting… read more here.
Keywords: common data; genetic epilepsy; task3 wg1b; data elements ... See more keywords
Social communication of affective states
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2020.12.007
Abstract: Social interactions promote the communication of explicit and implicit information between individuals. Implicit or subconscious sharing of cues can be useful in conveying affective states. Knowing the affective state of others can guide future interactions,… read more here.
Keywords: communication; affective state; rodent models; social communication ... See more keywords
The added value of rodent models in studying parental influence on offspring development: opportunities, limitations and future perspectives.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in psychology"
DOI: 10.1016/j.copsyc.2017.02.030
Abstract: Over the past decades, the influence of parental care on offspring development has been a topic of extensive research in both human and animal models. Rodent models offer several unique advantages over human studies, allowing… read more here.
Keywords: added value; rodent models; influence; offspring development ... See more keywords
Rodent models of diabetic kidney disease: human translatability and preclinical validity.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.05.004
Abstract: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD). Except for SGLT2 inhibitors and GLP-1R agonists, there have been few changes in DKD treatment over the past 25 years, when multifactorial… read more here.
Keywords: rodent models; diabetic kidney; disease; kidney disease ... See more keywords
Progress in developing rodent models of age-related macular degeneration (AMD).
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108404
Abstract: Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss, typically affecting individuals from mid-life onwards. Its multifactorial aetiology and the lack of any effective treatments has spurred the development of animal… read more here.
Keywords: macular degeneration; age related; related macular; rodent models ... See more keywords
Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113315
Abstract: Parkinson's disease (PD), a debilitating progressive degenerative movement disorder associated with loss of dopaminergic (DA) neurons in the substantia nigra (SN), afflicts approximately one million people in the U.S., including a significant number of Veterans.… read more here.
Keywords: calpain; cells rodent; disease; rodent models ... See more keywords
Current approaches to characterize micro- and macroscale circuit mechanisms of Parkinson’s disease in rodent models
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2022.114008
Abstract: Accelerating technological progress in experimental neuroscience is increasing the scale as well as specificity of both observational and perturbational approaches to study circuit physiology. While these techniques have also been used to study disease mechanisms,… read more here.
Keywords: rodent models; circuit; disease; parkinson disease ... See more keywords
Nondestructive and objective assessment of the vestibular function in rodent models: A review
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134608
Abstract: The normal function of the vestibular system is crucial for the sense of balance. The techniques used to assess the vestibular function plays a vital role in the research of the vestibular system. In this… read more here.
Keywords: vestibular evoked; vestibular function; rodent models; function rodent ... See more keywords
Antioxidant and anti-inflammatory effects of dexrazoxane on dopaminergic neuron degeneration in rodent models of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107758
Abstract: Emerging evidence has demonstrated that the integrity and the function of blood-brain barrier (BBB) are gradually impaired in the processes of aging and nervous system disorders, including neurodegenerative diseases (e.g. Parkinson's disease, PD). The leakage… read more here.
Keywords: antioxidant anti; dex; disease; rodent models ... See more keywords
Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.106651
Abstract: INTRODUCTION In animal models of non-alcoholic fatty liver disease (NAFLD), assessment of disease severity and treatment effects of drugs rely on histopathological scoring of liver biopsies. However, little is known about the sampling variation in… read more here.
Keywords: variation; paired liver; liver; rodent models ... See more keywords
Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b06534
Abstract: Air pollution is a diverse and dynamic mixture of gaseous and particulate matter, limiting our understanding of associated adverse health outcomes. The biological effects of two simulated smog atmospheres (SA) with different compositions but similar… read more here.
Keywords: simulated smog; atmospheres rodent; effects simulated; models metabolic ... See more keywords