The Mouse Model of Infection with Citrobacter rodentium
Sign Up to like & getrecommendations! Published in 2017 at "Current Protocols in Immunology"
DOI: 10.1002/cpim.34
Abstract: Citrobacter rodentium is a murine mucosal pathogen used as a model to elucidate the molecular and cellular pathogenesis of infection with two clinically important human gastrointestinal pathogens, enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli… read more here.
Keywords: rodentium; infection; mouse model; citrobacter rodentium ... See more keywords
Regulation of Citrobacter rodentium colonization: virulence, immune response and microbiota interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2021.07.003
Abstract: Citrobacter rodentium is a mouse-specific pathogen commonly used to model infection by human Enteropathogenic Escherichia coli, an important cause of infant diarrhea and mortality worldwide. In the early phase of infection, C. rodentium overcomes competition… read more here.
Keywords: microbiota; citrobacter rodentium; colonization; immune response ... See more keywords
Protective effects of oral immunization with formalin-inactivated whole-cell Citrobacter rodentium on Citrobacter rodentium infection in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiological methods"
DOI: 10.1016/j.mimet.2019.02.016
Abstract: Evaluation of the efficacy of vaccine candidates that prevent enteropathogenic and enterohemorrhagic Escherichia coli (EPEC/EHEC) infection in mouse models is difficult due to their limited pathogenicity in mice. Citrobacter rodentium, a murine pathogenic bacterium that… read more here.
Keywords: citrobacter rodentium; rodentium infection; infection; mice ... See more keywords
Loss of disease tolerance during Citrobacter rodentium infection is associated with impaired epithelial differentiation and hyperactivation of T cell responses
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17386-y
Abstract: Citrobacter rodentium is an intestinal mouse pathogen widely used as a model to study the mucosal response to infection. Inbred mouse strains suffer one of two fates following infection: self-limiting colitis or fatal diarrheal disease.… read more here.
Keywords: rodentium infection; infection; rodentium; disease tolerance ... See more keywords
Trained ILC3 responses promote intestinal defense
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.aaz8777
Abstract: Group 3 innate lymphoid cells (ILC3s) are innate immune effectors that contribute to host defense. Whether ILC3 functions are stably modified after pathogen encounter is unknown. Here, we assess the impact of a time-restricted enterobacterial… read more here.
Keywords: lymphoid; long term; trained ilc3; defense ... See more keywords
Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ
Sign Up to like & getrecommendations! Published in 2018 at "mBio"
DOI: 10.1128/mbio.00170-18
Abstract: ABSTRACT Tyrosine phosphorylation is key for signal transduction from exogenous stimuli, including the defense against pathogens. Conversely, pathogens can subvert protein phosphorylation to control host immune responses and facilitate invasion and dissemination. The bacterial effectors… read more here.
Keywords: bacterial adp; tyrosine; epec ehec; rodentium ... See more keywords
The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007406
Abstract: Infection with Citrobacter rodentium triggers robust tissue damage repair responses, manifested by secretion of IL-22, in the absence of which mice succumbed to the infection. Of the main hallmarks of C. rodentium infection are colonic… read more here.
Keywords: secretion; citrobacter rodentium; infection; rodentium ... See more keywords
Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008448
Abstract: The composition of the intestinal microbiota influences the outcome of enteric infections in human and mice. However, the role of specific members and their metabolites contributing to disease severity is largely unknown. Using isogenic mouse… read more here.
Keywords: citrobacter rodentium; infection; mice; rodentium ... See more keywords
Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008553
Abstract: IRGM and its mouse orthologue Irgm1 are dynamin-like proteins that regulate vesicular remodeling, intracellular microbial killing, and pathogen immunity. IRGM dysfunction is linked to inflammatory bowel disease (IBD), and while it is thought that defective… read more here.
Keywords: pathogen; susceptibility; citrobacter rodentium; dysfunction ... See more keywords
Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00608
Abstract: We have examined the influence of depleting plasmacytoid dendritic cells (pDC) in mice on the immune response to the gut pathogen Citrobacter rodentium, an organism that is a model for human attaching effacing pathogens such… read more here.
Keywords: depleted mice; dendritic cells; plasmacytoid dendritic; cells provide ... See more keywords
Mice Deficient in Epithelial or Myeloid Cell Iκκβ Have Distinct Colonic Microbiomes and Increased Resistance to Citrobacter rodentium Infection
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02062
Abstract: The colonic microenvironment, stemming from microbial, immunologic, stromal, and epithelial factors, serves as an important determinant of the host response to enteric pathogenic colonization. Infection with the enteric bacterial pathogen Citrobacter rodentium elicits a strong… read more here.
Keywords: citrobacter rodentium; deficient; infection; histopathology ... See more keywords