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   Articles with "roflumilast" as a keyword



Efficacy of Roflumilast Foam, 0.3%, in Patients With Seborrheic Dermatitis: A Double-blind, Vehicle-Controlled Phase 2a Randomized Clinical Trial.

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recommendations! Published in 2023 at "JAMA dermatology"

DOI: 10.1001/jamadermatol.2023.0846

Abstract: Importance Current topical treatment options for seborrheic dermatitis are limited by efficacy and/or safety. Objective To assess safety and efficacy of roflumilast foam, 0.3%, in adult patients with seborrheic dermatitis affecting the scalp, face, and/or… read more here.

Keywords: vehicle; roflumilast foam; seborrheic dermatitis; roflumilast ... See more keywords

A Single‐center, Open‐label, Parallel Control Study Comparing the Pharmacokinetics and Safety of a Single Oral Dose of Roflumilast and Its Active Metabolite Roflumilast N‐oxide in Healthy Chinese and Caucasian Volunteers

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recommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1209

Abstract: Roflumilast is a phosphodiesterase‐4 inhibitor which treats chronic obstructive pulmonary disease (COPD). Roflumilast N‐oxide is the major metabolite of roflumilast with a similar mechanism of action to roflumilast. Although racial differences in roflumilast drug disposition… read more here.

Keywords: roflumilast; chinese caucasian; roflumilast oxide; dose roflumilast ... See more keywords

Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial

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recommendations! Published in 2017 at "Psychopharmacology"

DOI: 10.1007/s00213-017-4770-y

Abstract: IntroductionSensory gating is a process involved in early information processing which prevents overstimulation of higher cortical areas by filtering sensory information. Research has shown that the process of sensory gating is disrupted in patients suffering… read more here.

Keywords: acute administration; healthy young; gating healthy; sensory gating ... See more keywords

An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients

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recommendations! Published in 2018 at "Psychopharmacology"

DOI: 10.1007/s00213-018-5134-y

Abstract: RationaleSchizophrenia is associated with impairments in cognitive functioning yet there are no approved drugs to treat these deficits.ObjectivesBased on animal models, we investigated the potential for roflumilast, a selective inhibitor of phosphodiesterase type 4 (PDE4),… read more here.

Keywords: medicine; working memory; schizophrenia patients; roflumilast ... See more keywords

Treatment of obesity-associated overactive bladder by the phosphodiesterase type-4 inhibitor roflumilast

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recommendations! Published in 2017 at "International Urology and Nephrology"

DOI: 10.1007/s11255-017-1671-2

Abstract: PurposeTo prove that phosphodiesterase type-4 inhibitors could potentially treat obesity-associated overactive bladder through modulation of the systemic inflammatory response.MethodsIn this 12-week study, 90 female Sprague–Dawley rats were divided into three groups: (1) vehicle-treated normal diet… read more here.

Keywords: phosphodiesterase type; treatment; bladder; associated overactive ... See more keywords

Design and characterization of emulsified spray dried alginate microparticles as a carrier for the dually acting drug roflumilast

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recommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2018.06.015

Abstract: &NA; Roflumilast is a selective inhibitor of phosphodiesterase‐4 isoenzyme in lung cells. Having psychiatric adverse reactions when administered orally affects negatively the patients' adherence to the drug. This work aimed to prepare emulsified spray dried… read more here.

Keywords: based microparticles; emulsified spray; drug; spray dried ... See more keywords
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Longstanding tracheobronchomalacia: A forgotten cause of severe cough and its response to roflumilast

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recommendations! Published in 2020 at "Respiratory Medicine Case Reports"

DOI: 10.1016/j.rmcr.2020.101247

Abstract: This case report describes a patient with moderately severe tracheobronchomalacia following mycoplasma pneumonia. The patient was considered to have obstructive lung disease despite no prior smoking or lung disease and failure to respond to standard… read more here.

Keywords: forgotten cause; longstanding tracheobronchomalacia; cough; tracheobronchomalacia forgotten ... See more keywords

Inhalable Formulation Based on Lipid–Polymer Hybrid Nanoparticles for the Macrophage Targeted Delivery of Roflumilast

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recommendations! Published in 2022 at "Biomacromolecules"

DOI: 10.1021/acs.biomac.2c00576

Abstract: Here, novel lipid–polymer hybrid nanoparticles (LPHNPs), targeted to lung macrophages, were realized as potential carriers for Roflumilast administration in the management of chronic obstructive pulmonary disease (COPD). To achieve this, Roflumilast-loaded fluorescent polymeric nanoparticles, based… read more here.

Keywords: roflumilast; lipid polymer; hybrid nanoparticles; inhalable formulation ... See more keywords

505 - Once-daily roflumilast cream 0.15% for atopic dermatitis: pooled results from INTEGUMENT-1/2 phase 3 trials

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recommendations! Published in 2024 at "British Journal of Dermatology"

DOI: 10.1093/bjd/ljad498.013

Abstract: Roflumilast cream 0.15% is a selective, highly potent phosphodiesterase 4 inhibitor under investigation as a non-steroidal, once-daily treatment for atopic dermatitis (AD). Here, pooled results from two identical Phase 3 randomized controlled trials (INTEGUMENT-1: NCT04773587… read more here.

Keywords: roflumilast cream; roflumilast; dermatitis pooled; atopic dermatitis ... See more keywords

Determination of Phosphodiesterase Inhibitors Tadalafil, Roflumilast and Roflumilast N-Oxide Using LC-MS in Guinea Pig Plasma.

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recommendations! Published in 2018 at "Journal of chromatographic science"

DOI: 10.1093/chromsci/bmy072

Abstract: Phosphodiesterases are known as a super-family of 11 isoenzymes, which can exert various functions based on their organ distribution. In this work, a rapid and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry method was developed… read more here.

Keywords: guinea; guinea pig; phosphodiesterase; roflumilast ... See more keywords

Positive effects of roflumilast on behavior, neuroinflammation, and white matter injury in mice with global cerebral ischemia

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recommendations! Published in 2021 at "Behavioural Pharmacology"

DOI: 10.1097/fbp.0000000000000640

Abstract: Inhibition of phosphodiesterase 4 (PDE4) is a promising pharmacological strategy for the treatment of cerebral ischemic conditions. To increase the relevance and increase the translational value of preclinical studies, it is important to conduct experiments… read more here.

Keywords: roflumilast; mice; effects roflumilast; cerebral ischemia ... See more keywords