Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2017.05.015
Abstract: While increased mitochondrial reactive oxygen species have been commonly implicated in a variety of disease states, their in vivo role in the pathogenesis of diabetic nephropathy remains controversial. Using a two-photon imaging approach with a genetically… read more here.
Keywords: reactive oxygen; oxygen species; redox; mitochondrial reactive ... See more keywords
A high-throughput real-time in vitro assay using mitochondrial targeted roGFP for screening of drugs targeting mitochondria
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.10.013
Abstract: Most toxic compounds including cancer drugs target mitochondria culminating in its permeabilization. Cancer drug-screening and toxicological testing of compounds require cost-effective and sensitive high-throughput methods to detect mitochondrial damage. Real-time methods for detection of mitochondrial… read more here.
Keywords: mitochondrial damage; real time; biology; rogfp ... See more keywords