Metformin Protects Against Sunitinib-induced Cardiotoxicity: Investigating the Role of AMPK
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001256
Abstract: Abstract: Sunitinib is associated with cardiotoxicity through inhibition of AMP-protein kinase (AMPK) signaling. By contrast, the common antidiabetic agent metformin has demonstrated cardioprotection through indirect AMPK activation. In this study, we investigate the effects of… read more here.
Keywords: sunitinib induced; sunitinib; cardiotoxicity; role ampk ... See more keywords
Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects
Sign Up to like & getrecommendations! Published in 2024 at "Aging and Disease"
DOI: 10.14336/ad.2024.1216
Abstract: Aging is a key risk factor for numerous diseases, including cardiac diseases. High energy demands of the heart require precise cellular energy sensing to prevent metabolic stress. AMPK and sirtuins are key intracellular metabolic sensors… read more here.
Keywords: role ampk; heart; aging heart; ampk sirtuins ... See more keywords
Role of AMPK in autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1015500
Abstract: Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved catabolic process that involves an intracellular degradation system in which cytoplasmic components, such… read more here.
Keywords: role ampk; ampk autophagy; ampk; process ... See more keywords