The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1674
Abstract: Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown. The aim of this study is to determine… read more here.
Keywords: role cathepsin; cathepsin; heart failure;
Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease
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DOI: 10.1111/acel.13531
Abstract: Experimental and clinical therapies in the field of Alzheimer's disease (AD) have focused on elimination of extracellular amyloid beta aggregates or prevention of cytoplasmic neuronal fibrillary tangles formation, yet these approaches have been generally ineffective.… read more here.
Keywords: nuclear lamina; role cathepsin; induction nuclear; cathepsin ... See more keywords
Role of Cathepsin S in Periodontal Inflammation and Infection
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/4786170
Abstract: Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human… read more here.
Keywords: cathepsin; role cathepsin; expression; cathepsin periodontal ... See more keywords
The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.615740
Abstract: Astrocytes may not only be involved in the clearance of Amyloid beta peptides (Aβ) in Alzheimer's disease (AD), but appear to produce N-terminally truncated Aβ (Aβn−x) independently of BACE1, which generates the N-Terminus of Aβ… read more here.
Keywords: cathepsin degradation; degradation; catb; production ... See more keywords