Emerging themes in cohesin cancer biology
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DOI: 10.1038/s41568-020-0270-1
Abstract: Mutations of the cohesin complex in human cancer were first discovered ~10 years ago. Since then, researchers worldwide have demonstrated that cohesin is among the most commonly mutated protein complexes in cancer. Inactivating mutations in… read more here.
Keywords: cancer; emerging themes; biology; role cohesin ... See more keywords
Biology and insights into the role of cohesin protease separase in human malignancies
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DOI: 10.1111/brv.12321
Abstract: Separase, an enzyme that resolves sister chromatid cohesion during the metaphase‐to‐anaphase transition, plays a pivotal role in chromosomal segregation and cell division. Separase protein, encoded by the extra spindle pole bodies like 1 (ESPL1) gene,… read more here.
Keywords: separase; insights role; biology; biology insights ... See more keywords