IgA nephropathy: new insights into the role of complement.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2018.03.009
Abstract: Glomerular complement deposition is common in IgA nephropathy, and recent genome-wide association studies point to a role of complement factor H and complement factor H-related proteins in disease susceptibility. A number of recent studies have… read more here.
Keywords: complement; role complement; nephropathy new; iga nephropathy ... See more keywords
Role of complement, anti-complement therapeutics, and other targeted immunotherapies in myasthenia gravis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2022.2082946
Abstract: ABSTRACT Introduction Several patients with myasthenia gravis (MG) do not adequately respond to available drugs or exhibit poor tolerance, necessitating the need for new therapies. Areas covered The paper discusses the rapidly evolving target-specific immunotherapies… read more here.
Keywords: myasthenia gravis; complement anti; complement; complement therapeutics ... See more keywords
The role of the complement system in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci90962
Abstract: In addition to being a component of innate immunity and an ancient defense mechanism against invading pathogens, complement activation also participates in the adaptive immune response, inflammation, hemostasis, embryogenesis, and organ repair and development. Activation… read more here.
Keywords: complement activation; complement system; role complement;
Editorial: The Role of Complement in Health and Disease
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01869
Abstract: 1 Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Łódz, Poland, Univ. Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France, Department of Immunology, Oslo University Hospital, University of Oslo, Oslo, Norway,… read more here.
Keywords: role complement; editorial role; university; complement health ... See more keywords
The Role of Complement in Organ Transplantation
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DOI: 10.3389/fimmu.2019.02380
Abstract: The current immunosuppressive protocols used in transplant recipients have improved short-term outcomes, but long-term allograft failure remains an important clinical problem. Greater understanding of the immunologic mechanisms that cause allograft failure are needed, as well… read more here.
Keywords: organ transplantation; complement organ; complement; role ... See more keywords
An update on the role of complement in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1007382
Abstract: As a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed… read more here.
Keywords: complement; hepatocellular carcinoma; complement system; role complement ... See more keywords
New Insights into the Role of the Complement System in Human Viral Diseases
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DOI: 10.3390/biom12020226
Abstract: The complement system (CS) is part of the human immune system, consisting of more than 30 proteins that play a vital role in the protection against various pathogens and diseases, including viral diseases. Activated via… read more here.
Keywords: system; role complement; complement system; viral diseases ... See more keywords
Role of Complement in the Onset of Age-Related Macular Degeneration
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050832
Abstract: Age-related macular degeneration (AMD) is a progressive degenerative disease of the central retina and the leading cause of severe loss of central vision in people over age 50. Patients gradually lose central visual acuity, compromising… read more here.
Keywords: related macular; age related; role; macular degeneration ... See more keywords
The role of complement in kidney disease.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical medicine"
DOI: 10.7861/clinmed.2019-0452
Abstract: While the complement cascade is an important component of the innate immune system, uncontrolled activation can cause severe disease. This concept is illustrated by the prototypical complement-mediated renal disease atypical haemolytic uraemic syndrome (aHUS), which… read more here.
Keywords: disease; complement; complement kidney; activation ... See more keywords