The role of dysregulated PI3Kdelta signaling in human autoimmunity *
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13067
Abstract: Better treatment of autoimmune diseases requires an improved understanding of the cellular and molecular mechanisms that lead to the breakdown of immune tolerance. The discovery of individuals with germline mutations in PIK3CD (which encodes the… read more here.
Keywords: role dysregulated; pi3kdelta signaling; autoimmunity; dysregulated pi3kdelta ... See more keywords
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade8939
Abstract: Somatic activating mutations of PIK3CA are associated with development of vascular malformations (VMs). Here, we describe a microfluidic model of PIK3CA-driven VMs consisting of human umbilical vein endothelial cells expressing PIK3CA activating mutations embedded in… read more here.
Keywords: vascular malformations; role dysregulated; pik3ca driven; model pik3ca ... See more keywords