Role of EZH2 in adipogenesis and obesity: Current state of the art and implications - A review.
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030344
Abstract: Obesity is characterized by excessive accumulation of adiposity and has been implicated in a strong predisposition to metabolic disorders and cancer, constituting one of the major public health issues worldwide. The formation of new mature… read more here.
Keywords: obesity; ezh2 adipogenesis; role ezh2; adipogenesis obesity ... See more keywords
Emerging role of EZH2 in rheumatic diseases: A comprehensive review
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.14416
Abstract: Enhancer of zeste homolog 2 (EZH2) is a histone methylated enzyme. It trimethylates histone 3 lysine 27 (H3K27) to regulate epigenetic processes. Recently, studies showed excessive expression of EZH2 in rheumatic diseases, such as systemic… read more here.
Keywords: diseases comprehensive; rheumatic diseases; role ezh2; ezh2 rheumatic ... See more keywords
A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis
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DOI: 10.1186/s40478-022-01336-5
Abstract: Pediatric high-grade gliomas, specifically diffuse midline gliomas, account for only 20% of clinical cases but are 100% fatal. A majority of the DMG cases are characterized by the signature K27M mutation in histone H3. The… read more here.
Keywords: role ezh2; tumor; tumor suppressor; ezh2 ... See more keywords
Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target
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DOI: 10.18632/oncotarget.16467
Abstract: Epigenetic modifications in cancer stem cells largely result in phenotypic and functional heterogeneity in many solid tumors. Increasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2,… read more here.
Keywords: ezh2 cancer; cancer stem; cancer; role ezh2 ... See more keywords
Role of EZH2 in Uterine Gland Development
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DOI: 10.3390/ijms232415665
Abstract: Enhancer of zeste homolog 2 (EZH2) is a core component of polycomb repressive complex 2 that plays a vital role in transcriptional repression of gene expression. Conditional ablation of EZH2 using progesterone receptor (Pgr)-Cre in… read more here.
Keywords: role ezh2; role; uterine gland; development ... See more keywords