Pivotal Role of Fyn Kinase in Parkinson's Disease and Levodopa-Induced Dyskinesia: a Novel Therapeutic Target?
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02201-z
Abstract: The exact etiology of Parkinson's disease (PD) remains obscure, although many cellular mechanisms including α-synuclein aggregation, oxidative damage, excessive neuroinflammation, and dopaminergic neuronal apoptosis are implicated in its pathogenesis. There is still no disease-modifying treatment… read more here.
Keywords: fyn; levodopa induced; role fyn; parkinson disease ... See more keywords
Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666211221153719
Abstract: Fyn kinase is a member of the Src non-receptor tyrosine kinase family. Fyn is involved in multiple signaling pathways extending from cell proliferation and differentiation to cell adhesion and cell motility, and it has been… read more here.
Keywords: kinase inhibitors; kinase; inhibitors switching; cell ... See more keywords