Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity.
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DOI: 10.1021/acs.biochem.1c00519
Abstract: The T-cell protein tyrosine phosphatase (TCPTP/PTPN2) targets a broad variety of substrates across different subcellular compartments. In spite of that, the structural basis for the regulation of TCPTP's activity remains elusive. Here, we investigated whether… read more here.
Keywords: role helix; tcptp; helix; activity ... See more keywords