A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2019.12.019
Abstract: BACKGROUND & AIMS Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver macrophages. However, also hepatocytes, the parenchymal cells of the liver, possess potent immunological functions in addition… read more here.
Keywords: hepatocyte intrinsic; canonical signaling; role hepatocyte; role ... See more keywords
Insights into the role of hepatocyte PPARα activity in response to fasting
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.07.035
Abstract: The liver plays a central role in the regulation of fatty acid metabolism. Hepatocytes are highly sensitive to nutrients and hormones that drive extensive transcriptional responses. Nuclear hormone receptors are key transcription factors involved in… read more here.
Keywords: ppar; insights role; role hepatocyte; role ... See more keywords
Critical role for hepatocyte-specific eNOS in NAFLD and NASH.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db20-1228
Abstract: Regulation of endothelial nitric oxide synthase (eNOS) in hepatocytes may be an important target in nonalcoholic fatty liver disease (NAFLD) development and progression to steatohepatitis (NASH). In this study, we show genetic deletion and viral… read more here.
Keywords: role hepatocyte; nafld nash; hepatocyte specific; hepatocyte ... See more keywords
The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1011230
Abstract: Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include… read more here.
Keywords: nuclear factor; factor; hepatocyte nuclear; role hepatocyte ... See more keywords