The role of human in the loop: lessons from D3R challenge 4
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-020-00291-4
Abstract: The rapid development of new machine learning techniques led to significant progress in the area of computer-aided drug design. However, despite the enormous predictive power of new methods, they lack explainability and are often used… read more here.
Keywords: human experts; human loop; loop lessons; role human ... See more keywords
The Emerging Role of Human TRPV1 S1 S4 Sensing Domain in Channel Gating
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.639
Abstract: Transient potential receptor ion channel vanilloid member 1, TRPV1, was initially identified as the capsaicin receptor, but is also modulated by various chemical and physical stimuli including elevated temperature, acidic pH, endogenous ligands and regulatory… read more here.
Keywords: trpv1; emerging role; role human; trpv1 sensing ... See more keywords
Role of human glutathione transferases in biotransformation of the nitric oxide prodrug JS-K
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00327-1
Abstract: Nitric oxide (NO) plays a prominent physiological role as a low-molecular-mass signal molecule involved in diverse biological functions. Great attention has been directed to pharmacologically modulating the release of NO for various therapeutic applications. We… read more here.
Keywords: human glutathione; role human; glutathione transferases; role ... See more keywords
The role of human factors in neonatal patient safety.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in perinatology"
DOI: 10.1053/j.semperi.2019.08.003
Abstract: The relationship between the fields of human factors and patient safety is relatively nascent but represents a powerful interaction that has developed in only the last twenty years. Application of human factors principles, techniques, and… read more here.
Keywords: neonatal patient; factors neonatal; patient safety; role human ... See more keywords
Mitochondria and Their Role in Human Reproduction.
Sign Up to like & getrecommendations! Published in 2019 at "DNA and cell biology"
DOI: 10.1089/dna.2019.4807
Abstract: Genetic defects of the mitochondrial genome can be especially devastating to patients; moreover, attention on human mitochondrial disorders has grown remarkably in recent years. Mitochondrial DNA (mtDNA) is maternally inherited in most eukaryotes, with paternal… read more here.
Keywords: role human; biology; mitochondria role; human reproduction ... See more keywords
Is There a Role for Human-Induced Climate Change in the Precipitation Decline that Drove the California Drought?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Climate"
DOI: 10.1175/jcli-d-17-0192.1
Abstract: AbstractThe recent California drought was associated with a persistent ridge at the west coast of North America that has been associated with, in part, forcing from warm SST anomalies in the tropical west Pacific. Here… read more here.
Keywords: role human; human induced; california drought; climate ... See more keywords
Ferroptosis Plays a Role in Human Chondrocyte of Osteoarthritis Induced by IL-1β In Vitro.
Sign Up to like & getrecommendations! Published in 2023 at "Cartilage"
DOI: 10.1177/19476035221142011
Abstract: OBJECTIVE Osteoarthritis (OA) is a common disease with complex and unclear pathogenesis. Ferroptosis is a new cell death mode, which is proved to be involved in different kinds of disease. We hypothesized that ferroptosis contributes… read more here.
Keywords: ferroptosis plays; chondrocyte; osteoarthritis; role human ... See more keywords
SRC-2 Coactivator: a role in human metabolic evolution and disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine"
DOI: 10.1186/s10020-020-00168-0
Abstract: The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary ‘master genes’ to direct the coordinate transcription of multiple genes required… read more here.
Keywords: human metabolic; evolution disease; role human; coactivator role ... See more keywords
Nucleophagy Plays a Major Role in Human Diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Current drug targets"
DOI: 10.2174/1389450119666180518112350
Abstract: Nucleophagy is a selective autophagy, which selectively removes damaged or non-essential nuclear material from a cell by the autophagy pathway. Additionally, nucleophagy is crucial for promoting cell longevity and ensure body proper function. Increasing evidence… read more here.
Keywords: major role; role human; nucleophagy; cell ... See more keywords
The Role of Human Centromeric RNA in Chromosome Stability
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.642732
Abstract: Chromosome instability is a hallmark of cancer and is caused by inaccurate segregation of chromosomes. One cellular structure used to avoid this fate is the kinetochore, which binds to the centromere on the chromosome. Human… read more here.
Keywords: centromeric rna; rna; role human; human centromeric ... See more keywords
The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2021.760914
Abstract: Hypothalamus (HT), this small structure often perceived through the prism of neuroimaging as morphologically and functionally homogeneous, plays a key role in the primitive act of feeding. The current paper aims at reviewing the contribution… read more here.
Keywords: human hypothalamus; food intake; hypothalamus food; role ... See more keywords