Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity
Sign Up to like & getrecommendations! Published in 2022 at "Adipocyte"
DOI: 10.1080/21623945.2022.2089394
Abstract: ABSTRACT High fat diet (HFD)-induced obesity leads to perturbation in the storage function of white adipose tissue (WAT) resulting in deposition of lipids in tissues ill-equipped to deal with this challenge. The role of insulin… read more here.
Keywords: hfd; role; cixutumumab; induced obesity ... See more keywords
Role of IGF-binding proteins in regulating IGF responses to changes in metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-18-0016
Abstract: The IGF-binding protein family contains six members that share significant structural homology. Their principal function is to regulate the actions of IGF1 and IGF2. These proteins are present in plasma and extracellular fluids and regulate… read more here.
Keywords: igf binding; binding proteins; role igf; physiology ... See more keywords
Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.641449
Abstract: Over the last two decades, many studies have demonstrated that the insulin-like growth factor-1 (IGF-1) is involved in a number of patho-physiological processes, as well as in the development of different types of solid tumors,… read more here.
Keywords: igf axis; breast cancer; role igf; igf ... See more keywords
ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00027
Abstract: Human aging is currently defined as a physiological decline of biological functions in the body with a continual adaptation to internal and external damaging. The endocrine system plays a major role in orchestrating cellular interactions,… read more here.
Keywords: longevity; system; igf system; role igf ... See more keywords