A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2
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DOI: 10.1523/eneuro.0055-17.2017
Abstract: Abstract A plethora of neurological disorders are associated with alterations in the expression and localization of potassium-chloride cotransporter type 2 (KCC2), making KCC2 a critical player in neuronal function and an attractive target for therapeutic… read more here.
Keywords: role intracellular; role; potassium chloride; chloride cotransporter ... See more keywords
Role of Intracellular Na+ in the Regulation of [Ca2+]i in the Rat Suprachiasmatic Nucleus Neurons
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DOI: 10.3390/ijms20194868
Abstract: Transmembrane Ca2+ influx is essential to the proper functioning of the central clock in the suprachiasmatic nucleus (SCN). In the rat SCN neurons, the clearance of somatic Ca2+ following depolarization-induced Ca2+ transients involves Ca2+ extrusion… read more here.
Keywords: role intracellular; role; ca2; suprachiasmatic nucleus ... See more keywords
Role of Intracellular Amyloid β as Pathway Modulator, Biomarker, and Therapy Target
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DOI: 10.3390/ijms23094656
Abstract: The β- and γ-secretase-driven cleavage of the amyloid precursor protein (APP) gives rise to the amyloid β peptide, which is believed to be the main driver of neurodegeneration in Alzheimer’s disease (AD). As it is… read more here.
Keywords: pathway modulator; modulator biomarker; role; intracellular amyloid ... See more keywords