Abstract A019: The role of KRAS ubiquitination in lung cancer heterogeneity
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-a019
Abstract: Lung cancer is the most frequent cancer with an aggressive clinical course and high mortality rates. About 30% of non-small lung cancer is driven by activating mutations in KRAS (Kirsten rat sarcoma virus). KRAS signaling… read more here.
Keywords: role kras; lung cancer; lztr1; kras ubiquitination ... See more keywords
An emerging role of KRAS in biogenesis, cargo sorting and uptake of cancer-derived extracellular vesicles.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2021-0332
Abstract: Extracellular vesicles (EVs) are nanovesicles secreted for intercellular communication with endosomal network regulating secretion of small EVs (or exosomes) that play roles in cancer progression. As an essential oncoprotein, Kirsten rat sarcoma virus (KRAS) is… read more here.
Keywords: role kras; extracellular vesicles; biogenesis cargo; cancer ... See more keywords
Role of KRAS in NSCLC: present and future
Sign Up to like & getrecommendations! Published in 2018 at "Genetics and Molecular Research"
DOI: 10.4238/gmr16039873
Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide. Despite therapeutic advances over the last several decades, the overall 5-year survival remains only 16%. (Siegel R, 2013). Molecular studies have indicated that Adenocarcinomas have… read more here.
Keywords: kras nsclc; nsclc present; cancer; present future ... See more keywords