The role of LRRK2 in cytoskeletal dynamics.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20180469
Abstract: Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional cytoskeleton for… read more here.
Keywords: lrrk2 cytoskeletal; role lrrk2; cytoskeletal dynamics;
The role of LRRK2 on PKA-NFκB pathway in microglia cells: implications for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.257523
Abstract: Leucine-rich repeat kinase 2 (LRRK2), a gene linked to autosomal-dominantly inherited and sporadic Parkinson’s disease (PD) as a risk factor, encodes a large and complex protein with a dual enzymatic activity. LRRK2 contains several domains… read more here.
Keywords: role lrrk2; lrrk2 pka; microglia; parkinson disease ... See more keywords