The role and mechanism of unfolded protein response signaling pathway in methylmercury‐induced apoptosis of mouse spermatocytes germ cell‐2 cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23684
Abstract: The study aimed to explore the role and mechanism of unfolded protein response (UPR) in methylmercury (MeHg)‐induced Mouse Spermatocytes (GC‐2spd[ts]) apoptosis. Methods such as MTT, flow cytometry, and Western Blot were used to evaluate the… read more here.
Keywords: cell; unfolded protein; apoptosis; mechanism unfolded ... See more keywords
The role and mechanism of CARD9 gene polymorphism in diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical journal"
DOI: 10.1016/j.bj.2020.12.006
Abstract: CARD9 is a cytosolic adaptor in myeloid cells, has a critical role in inflammatory disorders, and provides a protective function against microbial pathogen, especially fungal infection. Recently, CARD9 polymorphisms are of interest, showing a positive… read more here.
Keywords: gene polymorphism; role mechanism; card9 polymorphisms; role ... See more keywords
Biological role and mechanism of chromatin readers in plants.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2021.102008
Abstract: Epigenetic modifications are important gene regulatory mechanisms conserved in plants, animals, and fungi. Chromatin reader domains are protein-protein/DNA interaction modules acting within the chromatin-modifying complex to function as molecular interpreters of the epigenetic code. Understanding… read more here.
Keywords: reader proteins; reader; role mechanism; chromatin ... See more keywords
The Positive Role and Mechanism of Herbal Medicine in Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/9923331
Abstract: Parkinson's disease (PD) is a complex neurodegenerative disease, manifested by the progressive functional impairment of the midbrain nigral dopaminergic neurons. Due to the unclear underlying pathogenesis, disease-modifying drugs for PD remain elusive. In Asia, such… read more here.
Keywords: medicine; role mechanism; disease; herbal medicines ... See more keywords
Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/8955322
Abstract: Objective To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). Methods The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete… read more here.
Keywords: mechanism lncrna; pvt1 pathogenesis; role mechanism; acute lymphoblastic ... See more keywords
Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions
Sign Up to like & getrecommendations! Published in 2024 at "Aging and Disease"
DOI: 10.14336/ad.2024.0126
Abstract: In modern times, a notable trend toward delayed childbearing has been observed in most developed countries. As a result, sperm aging and quality loss, as well as premature ovarian failure (POF), have emerged as major… read more here.
Keywords: pof; role mechanism; sperm aging; aging pof ... See more keywords
The Role and Mechanism of Autophagy in Pancreatic Cancer: An Update Review
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Management and Research"
DOI: 10.2147/cmar.s328786
Abstract: Abstract Pancreatic cancer, with high morbidity and mortality rates, is one of the most malignant tumors worldwide. Despite extensive research, the prognosis remains poor. Autophagy, a lysosomal-mediated, highly conserved degradation process that removes abnormal proteins… read more here.
Keywords: mechanism autophagy; pancreatic cancer; cancer; autophagy pancreatic ... See more keywords
Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.820936
Abstract: Circular RNAs (circRNAs) are non-coding RNAs with covalent closed-loop structures and are widely distributed in eukaryotes, conserved and stable as well as tissue-specific. Malignant solid tumors pose a serious health risk to children and are… read more here.
Keywords: malignant solid; solid tumors; role mechanism; mechanism circrnas ... See more keywords
The role and mechanism of histone lactylation in health and diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.949252
Abstract: Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate. Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that develops non-metabolic activities in addition to serving as a key metabolite… read more here.
Keywords: lactylation; histone lactylation; role mechanism; mechanism histone ... See more keywords
The role and mechanism of bacterial outer membrane vesicles in the development of periodontitis
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1654137
Abstract: Outer membrane vesicles (OMVs), nanoscale structures actively secreted by Gram-negative bacteria, have emerged as critical pathogenic components in periodontitis. While periodontitis has traditionally been associated with biofilm accumulation and bacterial colonization, recent studies highlight that… read more here.
Keywords: role mechanism; outer membrane; periodontitis; membrane vesicles ... See more keywords
The role and mechanism of claudins in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1051497
Abstract: Claudins are a tetraspan membrane protein multigene family that plays a structural and functional role in constructing tight junctions. Claudins perform crucial roles in maintaining cell polarity in epithelial and endothelial cell sheets and controlling… read more here.
Keywords: mechanism claudins; cell; role; role mechanism ... See more keywords