Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101789
Abstract: Heme oxygenase-1 (HO-1) is an inducible enzyme known for its anti-inflammatory, antioxidant and neuroprotective effects. However, increased expression of HO-1 during aging and age-related neurodegenerative diseases have been associated to neurotoxic ferric iron deposits. Being… read more here.
Keywords: metabolism; iron; aged mice; role microglial ... See more keywords
What Is the Role of Microglial Metabolism in Inflammation and Neurodegeneration?
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200920
Abstract: Microglia constitute the brain innate immune system and are epigenetically and transcriptionally distinct from other tissue-resident and bone marrow–derived macrophages.1,2 Under physiologic conditions, microglia actively survey their environment and maintain a unique gene expression signature… read more here.
Keywords: inflammation neurodegeneration; microglial metabolism; metabolism inflammation; receptors receptors ... See more keywords
The role of microglial autophagy in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1039780
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disease. Studies have shown that abnormal accumulation of α-synuclein (α-Syn) in the substantia nigra is a specific pathological characteristic of PD. Abnormal accumulation of α-Syn in… read more here.
Keywords: microglial autophagy; parkinson disease; role microglial; autophagy ... See more keywords
Key Role of Microglial Matrix Metalloproteinases in Choroidal Neovascularization
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.638098
Abstract: Age-related macular degeneration (AMD), especially neovascular AMD with choroidal neovascularization (CNV), is the leading cause of blindness in the elderly. Although matrix metalloproteinases (MMPs) are involved in pathological ocular angiogenesis, including CNV, the cellular origin… read more here.
Keywords: choroidal neovascularization; role microglial; mmp; cnv ... See more keywords
Role of Microglial Cells in the Pathophysiology of MS: Synergistic or Antagonistic?
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24031861
Abstract: Many studies indicate an important role of microglia and their cytokines in the pathophysiology of multiple sclerosis (MS). Microglia are the macrophages of the central nervous system (CNS). They have many functions, such as being… read more here.
Keywords: cells pathophysiology; pathophysiology synergistic; microglial cells; role ... See more keywords
The Role of Microglial Purinergic Receptors in Pain Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27061919
Abstract: Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal and… read more here.
Keywords: microglial purinergic; role; purinergic receptors; receptors pain ... See more keywords