Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_117
Abstract: Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by… read more here.
Keywords: reactive oxygen; oxygen species; mitochondrial superoxide; mitochondrial reactive ... See more keywords
Possible role of mitochondrial injury in Caulis Aristolochia manshuriensis-induced chronic aristolochic acid nephropathy
Sign Up to like & getrecommendations! Published in 2017 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2016.1188303
Abstract: Abstract Context: The proximal tubular epithelial cells (PTECs) are the primary target of aristolochic acids and especially vulnerable to mitochondrial injury from insults of toxic xenobiotics. Objectives: This study aimed to investigate the possible role… read more here.
Keywords: week; mitochondrial injury; possible role; injury caulis ... See more keywords
The role of mitochondrial transfer via tunneling nanotubes in the central nervous system: A review
Sign Up to like & getrecommendations! Published in 2024 at "Medicine"
DOI: 10.1097/md.0000000000037352
Abstract: Tumour necrosis factor alpha-induced protein 2 (TNFAIP2) is a gene induced by tumor necrosis factor in endothelial cells. TNFAIP2 has important functions in physiological and pathological processes, including cell proliferation, adhesion, migration, angiogenesis, inflammation, tunneling… read more here.
Keywords: transfer via; via tunneling; mitochondrial transfer; transfer ... See more keywords
The emergent role of mitochondrial surveillance in cellular health
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13710
Abstract: Mitochondrial dysfunction is one of the primary causatives for many pathologies, including neurodegenerative diseases, cancer, metabolic disorders, and aging. Decline in mitochondrial functions leads to the loss of proteostasis, accumulation of ROS, and mitochondrial DNA… read more here.
Keywords: mitochondrial surveillance; surveillance; surveillance cellular; role mitochondrial ... See more keywords
Role of mitochondrial membrane permeabilization and depolarization in platelet apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.14903
Abstract: Liu, Y.S., Yu, Z.Y., Yin, X.Y., Zhang, F.Y., Yang, S., Zhou, Y. & Zhang, X.J. (2010) Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nature Genetics, 42, 614–618. Xu, S.,… read more here.
Keywords: genetics; zhang; membrane permeabilization; permeabilization depolarization ... See more keywords
FRI0252 Testing for a causal role of mitochondrial variation in the development of gout
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.5017
Abstract: Background Mitochondria execute critical roles in diverse cellular pathways. As a danger signal mitochondria induce inflammation in response to stress through NLRP3 inflammasome activation, central to gout development. We recently reported association of reduced mtDNA… read more here.
Keywords: copy number; mtdna; causal role; association ... See more keywords
The Role of Mitochondrial Dynamin in Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2504798
Abstract: Stroke is one of the leading causes of death and disability in the world. However, the pathophysiological process of stroke is still not fully clarified. Mitochondria play an important role in promoting nerve survival and… read more here.
Keywords: role; role mitochondrial; dynamin stroke; mitochondrial dynamin ... See more keywords
The role of mitochondrial transfer in lung disease
Sign Up to like & getrecommendations! Published in 2025 at "Respiratory Research"
DOI: 10.1186/s12931-025-03408-1
Abstract: Mitochondria are the energy factories, signaling hubs, and metabolic regulatory centers of cells, and their structural and functional integrity is essential for maintaining tissue homeostasis. Recent studies have revealed that mitochondria can be actively transferred… read more here.
Keywords: transfer lung; mitochondrial transfer; transfer; role mitochondrial ... See more keywords
What Is the Role of Mitochondrial Fission in Neurologic Disease?
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200233
Abstract: Mitochondria have multiple essential functions in cells, including energy production through oxidative phosphorylation, calcium and reactive oxygen species (ROS) signaling, biosynthesis of nucleotides, amino acids, and lipids, and apoptosis. Mitochondria exist as a network of… read more here.
Keywords: fission neurologic; fission; neurologic disease; mitochondrial fission ... See more keywords
What Is the Role of Mitochondrial Dysfunction in Programmed Axon Death?
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200691
Abstract: Axonal loss occurs in many neurologic disorders and its prevention is a major target of disease-modifying therapies. Over the past several years, studies in the Wlds mutant mouse model characterized by delayed Wallerian degeneration (WD)… read more here.
Keywords: mitochondrial dysfunction; programmed axon; role mitochondrial; axon death ... See more keywords
Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations.
Sign Up to like & getrecommendations! Published in 2025 at "Aging and disease"
DOI: 10.14336/ad.2024.1469
Abstract: Since the association between mitochondria and aging was first identified, significant efforts have been devoted to elucidating the role of mitochondrial DNA mutations in the aging process. Due to their age-dependent accumulation, intrinsically high mutation… read more here.
Keywords: dna mutations; role; mutations aging; theoretical expectations ... See more keywords