Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_117
Abstract: Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by… read more here.
Keywords: reactive oxygen; oxygen species; mitochondrial superoxide; mitochondrial reactive ... See more keywords
Possible role of mitochondrial injury in Caulis Aristolochia manshuriensis-induced chronic aristolochic acid nephropathy
Sign Up to like & getrecommendations! Published in 2017 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2016.1188303
Abstract: Abstract Context: The proximal tubular epithelial cells (PTECs) are the primary target of aristolochic acids and especially vulnerable to mitochondrial injury from insults of toxic xenobiotics. Objectives: This study aimed to investigate the possible role… read more here.
Keywords: week; mitochondrial injury; possible role; injury caulis ... See more keywords
The emergent role of mitochondrial surveillance in cellular health
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13710
Abstract: Mitochondrial dysfunction is one of the primary causatives for many pathologies, including neurodegenerative diseases, cancer, metabolic disorders, and aging. Decline in mitochondrial functions leads to the loss of proteostasis, accumulation of ROS, and mitochondrial DNA… read more here.
Keywords: mitochondrial surveillance; surveillance; surveillance cellular; role mitochondrial ... See more keywords
Role of mitochondrial membrane permeabilization and depolarization in platelet apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.14903
Abstract: Liu, Y.S., Yu, Z.Y., Yin, X.Y., Zhang, F.Y., Yang, S., Zhou, Y. & Zhang, X.J. (2010) Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nature Genetics, 42, 614–618. Xu, S.,… read more here.
Keywords: genetics; zhang; membrane permeabilization; permeabilization depolarization ... See more keywords
FRI0252 Testing for a causal role of mitochondrial variation in the development of gout
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.5017
Abstract: Background Mitochondria execute critical roles in diverse cellular pathways. As a danger signal mitochondria induce inflammation in response to stress through NLRP3 inflammasome activation, central to gout development. We recently reported association of reduced mtDNA… read more here.
Keywords: copy number; mtdna; causal role; association ... See more keywords
The Role of Mitochondrial Dynamin in Stroke
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DOI: 10.1155/2022/2504798
Abstract: Stroke is one of the leading causes of death and disability in the world. However, the pathophysiological process of stroke is still not fully clarified. Mitochondria play an important role in promoting nerve survival and… read more here.
Keywords: role; role mitochondrial; dynamin stroke; mitochondrial dynamin ... See more keywords
What Is the Role of Mitochondrial Fission in Neurologic Disease?
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200233
Abstract: Mitochondria have multiple essential functions in cells, including energy production through oxidative phosphorylation, calcium and reactive oxygen species (ROS) signaling, biosynthesis of nucleotides, amino acids, and lipids, and apoptosis. Mitochondria exist as a network of… read more here.
Keywords: fission neurologic; fission; neurologic disease; mitochondrial fission ... See more keywords
What Is the Role of Mitochondrial Dysfunction in Programmed Axon Death?
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200691
Abstract: Axonal loss occurs in many neurologic disorders and its prevention is a major target of disease-modifying therapies. Over the past several years, studies in the Wlds mutant mouse model characterized by delayed Wallerian degeneration (WD)… read more here.
Keywords: mitochondrial dysfunction; programmed axon; role mitochondrial; axon death ... See more keywords
New insights into signal transduction pathways in adrenal steroidogenesis: role of mitochondrial fusion, lipid mediators, and MAPK phosphatases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1175677
Abstract: Hormone-receptor signal transduction has been extensively studied in adrenal gland. Zona glomerulosa and fasciculata cells are responsible for glucocorticoid and mineralocorticoid synthesis by adrenocorticotropin (ACTH) and angiotensin II (Ang II) stimulation, respectively. Since the rate-limiting… read more here.
Keywords: signal transduction; mitochondrial fusion; steroidogenesis; role mitochondrial ... See more keywords
The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer
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DOI: 10.3390/biomedicines10020428
Abstract: MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However,… read more here.
Keywords: lung cancer; role mitochondrial; cancer; mitochondrial mirnas ... See more keywords
Signaling Role of Mitochondrial Enzymes and Ultrastructure in the Formation of Molecular Mechanisms of Adaptation to Hypoxia
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168636
Abstract: This study was the first comprehensive investigation of the dependence of mitochondrial enzyme response (catalytic subunits of mitochondrial complexes (MC) I-V, including NDUFV2, SDHA, Cyt b, COX1 and ATP5A) and mitochondrial ultrastructure in the rat… read more here.
Keywords: role mitochondrial; enzymes ultrastructure; signaling role; mitochondrial enzymes ... See more keywords