Abstract PO-040: The role of mTOR in epigenetic regulation in cancer
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DOI: 10.1158/1538-7445.epimetab20-po-040
Abstract: Changes in gene expression, including those caused by epigenetic dysregulation, represent a hallmark of cancer. The mechanistic/mammalian Target of Rapamycin (mTOR) is a serine/threonine kinase that coordinates nutrient availability to the regulation of cell growth… read more here.
Keywords: mtor epigenetic; mtor; role mtor; cancer ... See more keywords
New Insights Into the Role of mTOR Signaling in the Cardiovascular System.
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DOI: 10.1161/circresaha.117.311147
Abstract: The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form… read more here.
Keywords: mtor signaling; signaling cardiovascular; mtor; role mtor ... See more keywords
The role of the mTOR pathway in models of drug-induced reward and the behavioural constituents of addiction
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DOI: 10.1177/0269881120944159
Abstract: Background: Exposure to drugs of abuse induces neuroadaptations in critical nodes of the so-called reward systems that are thought to mediate the transition from controlled drug use to the compulsive drug-seeking that characterizes addictive disorders.… read more here.
Keywords: mtor pathway; models drug; drug; mtor ... See more keywords
The Cutting Edge: The Role of mTOR Signaling in Laminopathies
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DOI: 10.3390/ijms20040847
Abstract: The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase that regulates anabolic and catabolic processes, in response to environmental inputs. The existence of mTOR in numerous cell compartments explains its specific ability to… read more here.
Keywords: cutting edge; edge role; signaling laminopathies; mtor signaling ... See more keywords
Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential
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DOI: 10.3390/ijms23031693
Abstract: The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in the regulation of cell proliferation, survival, and motility in response to availability of energy and nutrients as well as mitogens. The mTOR… read more here.
Keywords: predominant role; skin diseases; mtor signaling; mtor ... See more keywords