Abstract PO-040: The role of mTOR in epigenetic regulation in cancer
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DOI: 10.1158/1538-7445.epimetab20-po-040
Abstract: Changes in gene expression, including those caused by epigenetic dysregulation, represent a hallmark of cancer. The mechanistic/mammalian Target of Rapamycin (mTOR) is a serine/threonine kinase that coordinates nutrient availability to the regulation of cell growth… read more here.
Keywords: mtor epigenetic; mtor; role mtor; cancer ... See more keywords
New Insights Into the Role of mTOR Signaling in the Cardiovascular System.
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DOI: 10.1161/circresaha.117.311147
Abstract: The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form… read more here.
Keywords: mtor signaling; signaling cardiovascular; mtor; role mtor ... See more keywords
The role of the mTOR pathway in models of drug-induced reward and the behavioural constituents of addiction
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DOI: 10.1177/0269881120944159
Abstract: Background: Exposure to drugs of abuse induces neuroadaptations in critical nodes of the so-called reward systems that are thought to mediate the transition from controlled drug use to the compulsive drug-seeking that characterizes addictive disorders.… read more here.
Keywords: mtor pathway; models drug; drug; mtor ... See more keywords
The Role of mTOR in Mycobacterium tuberculosis Infection
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DOI: 10.3390/biomedicines12102238
Abstract: Background/Objectives: Mycobacterium tuberculosis (M. tb) is a pathogen that causes tuberculosis (TB), an extremely infectious disease which is responsible for millions of deaths worldwide. The severity of this pathogen is further amplified with the emergence… read more here.
Keywords: tuberculosis; infection; mycobacterium tuberculosis; mtor ... See more keywords
The Cutting Edge: The Role of mTOR Signaling in Laminopathies
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DOI: 10.3390/ijms20040847
Abstract: The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase that regulates anabolic and catabolic processes, in response to environmental inputs. The existence of mTOR in numerous cell compartments explains its specific ability to… read more here.
Keywords: cutting edge; edge role; signaling laminopathies; mtor signaling ... See more keywords
Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential
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DOI: 10.3390/ijms23031693
Abstract: The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in the regulation of cell proliferation, survival, and motility in response to availability of energy and nutrients as well as mitogens. The mTOR… read more here.
Keywords: predominant role; skin diseases; mtor signaling; mtor ... See more keywords
Deciphering the intricate role of mTOR signaling and autophagy in Parkinson’s disease and therapeutic prospects
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Pharmaceutical Science"
DOI: 10.7324/japs.2023.156692
Abstract: The mammalian/mechanistic target of rapamycin (mTOR) has a prominent role in many neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease (PD). mTOR and autophagy have a definitive role in the pathogenesis of PD. mTOR… read more here.
Keywords: mtor signaling; role; mtor; role mtor ... See more keywords