Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin
Sign Up to like & getrecommendations! Published in 2021 at "Medical Hypotheses"
DOI: 10.1016/j.mehy.2021.110588
Abstract: Daily new information emerges regarding the COVID-19, infection of SARS-CoV-2, which is considered a global pandemic. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are required to complete the viral invasion pathway and… read more here.
Keywords: role nlrp3; covid; nlrp3 inflammasome; inflammasome covid ... See more keywords
Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15788
Abstract: Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged as the most common form of dementia in the elderly. Several pathological hallmarks have been identified, including neuroinflammation. A comprehensive insight into the underlying mechanisms that… read more here.
Keywords: alzheimer disease; therapeutic role; role nlrp3; mechanistic therapeutic ... See more keywords
The Role of NLRP3 Inflammasome Signaling on Arrhythmias in Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s390310
Abstract: Abstract Diabetes is a significant risk factor for arrhythmias. However, the pathophysiology of diabetes-related arrhythmias still needs to be elucidated, presumably associated with structural and electrical remodeling. There is growing evidence that inflammation and arrhythmias… read more here.
Keywords: role; related arrhythmias; inflammasome signaling; diabetes related ... See more keywords
The role of NLRP3 inflammasome in digestive system malignancy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1051612
Abstract: Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome… read more here.
Keywords: system malignancy; system; digestive system; role nlrp3 ... See more keywords
Investigating the Role of the NLRP3 Inflammasome Pathway in Acute Intestinal Inflammation: Use of THP-1 Knockout Cell Lines in an Advanced Triple Culture Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.898039
Abstract: The NLRP3 inflammasome plays an important role in intestinal homeostasis as well as inflammation. However, in vivo studies investigating the role of the NLRP3 inflammasome in inflammatory bowel disease (IBD) report contrasting results, leaving it… read more here.
Keywords: inflammation; role nlrp3; model; intestinal inflammation ... See more keywords
Role of NLRP3 Inflammasome in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.931690
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by multi-articular, symmetrical and invasive arthritis resulting from immune system abnormalities involving T and B lymphocytes. Although significant progress has been made in the understanding of… read more here.
Keywords: rheumatoid arthritis; role nlrp3; nlrp3 inflammasome; arthritis ... See more keywords
The role of NLRP3 inflammasome in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1150325
Abstract: Inflammasomes play an important role in innate immunity. As a signal platform, they deal with the excessive pathogenic products and cellular products related to stress and injury. So far, the best studied and most characteristic… read more here.
Keywords: hepatocellular carcinoma; role; hcc; role nlrp3 ... See more keywords
The Role of the NLRP3 Inflammasome in HCC Carcinogenesis and Treatment: Harnessing Innate Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133150
Abstract: Simple Summary The Hepatocellular Carcinoma (HCC) remains a major concern for the public health. The pandemic of metabolic syndrome in the Western societies and the considerable amounts of viral hepatitis in the underdeveloped countries keep… read more here.
Keywords: inflammasome hcc; hcc; hcc carcinogenesis; role nlrp3 ... See more keywords
Emerging Role of NLRP3 Inflammasome/Pyroptosis in Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158363
Abstract: Huntington’s disease (HD) is a neurodegenerative disease characterized by several symptoms encompassing movement, cognition, and behavior. The mutation of the IT15 gene encoding for the huntingtin protein is the cause of HD. Mutant huntingtin interacts… read more here.
Keywords: huntington disease; disease; emerging role; role nlrp3 ... See more keywords
Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214396
Abstract: The nucleotide-binding domain leucine-rich repeat-receptor, pyrin domain-containing-3 (NLRP3) inflammasome contributes to the inflammatory response by activating caspase-1, which in turn participates in the maturation of interleukin (IL)-1β and IL-18, which are mainly secreted via pyroptosis.… read more here.
Keywords: pyroptosis; inflammasome pyroptosis; role nlrp3; liver transplantation ... See more keywords