New insights into the role of the Nrf2 signaling pathway in green tea catechin applications
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7033
Abstract: Nuclear factor‐erythroid 2‐related factor 2 (Nrf2) is a transcriptional signaling pathway that plays a crucial role in numerous clinical complications. Pivotal roles of Nrf2 have been proved in cancer, autoimmune diseases, neurodegeneration, cardiovascular diseases, diabetes… read more here.
Keywords: green tea; role nrf2; tea catechins; signaling pathway ... See more keywords
The role of Nrf2 in mitigating cadmium-induced oxidative stress of Marsupenaeus japonicus.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.116112
Abstract: Nuclear factor-erythroid 2-related factor-2 (Nrf2) is an important modulator of cellular responses against Cd in mammalian cells. However, whether such modulation is conserved in Marsupenaeus japonicas remains unknown.In our study, the shrimps were injected with… read more here.
Keywords: role nrf2; stress; nrf2 mitigating; japonicus ... See more keywords
Protective effects of natural compounds against paraquat-induced pulmonary toxicity: the role of the Nrf2/ARE signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of environmental health research"
DOI: 10.1080/09603123.2022.2163985
Abstract: Paraquat (PQ) is a toxic herbicide to humans. Once absorbed, it accumulates in the lungs. PQ has been well documented that the generation of reactive oxygen species (ROS) is the main mechanism of its toxicity.… read more here.
Keywords: natural compounds; nrf2 signaling; toxicity; pulmonary toxicity ... See more keywords
The role of Nrf2 in immune cells and inflammatory autoimmune diseases: a comprehensive review
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2024.2401518
Abstract: ABSTRACT Introduction Nrf2 regulates mild stress, chronic inflammation, and metabolic changes by regulating different immune cells via downstream signaling. Collection of information about the role of Nrf2 in inflammatory autoimmune diseases will better understand the… read more here.
Keywords: role nrf2; immune cells; autoimmune diseases; inflammatory autoimmune ... See more keywords
Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/4683943
Abstract: Cardiocerebral vascular disease (CCVD) is a common disease with high morbidity, disability, and mortality. Oxidative stress (OS) is closely related to the progression of CCVD. Abnormal redox regulation leads to OS and overproduction of reactive… read more here.
Keywords: role nrf2; vascular disease; signaling pathway; cardiocerebral vascular ... See more keywords
The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Cardiology Research and Practice"
DOI: 10.1155/2022/4287711
Abstract: Cardiovascular disease (CVD) is a serious public health issue in China, accounting for more than 40% of all mortality, and it is the leading cause of death worldwide. Atherosclerosis is the pathological basis for much… read more here.
Keywords: factor; atherosclerosis; beneficial role; role nrf2 ... See more keywords
Abstract 4666: Unraveling the role of Nrf2 in the acute myeloid leukemia: implication for therapeutic targeting
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4666
Abstract: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by uncontrolled proliferation of myeloid precursor cells, presenting significant therapeutic challenges. NRF2 (Nuclear factor erythroid 2-related factor 2) is a transcription factor that regulates cellular defense… read more here.
Keywords: expression; role nrf2; acute myeloid; myeloid leukemia ... See more keywords
Role of Nrf2 in Epilepsy Treatment.
Sign Up to like & getrecommendations! Published in 2024 at "Current molecular medicine"
DOI: 10.2174/0115665240305987240918103602
Abstract: Oxidative stress is a consequence of the disruption of the balance between the generation of reactive nitrogen and oxygen species and the biological system's ability to neutralize those reactive products. Oxidative stress is involved in… read more here.
Keywords: role nrf2; nrf2 epilepsy; stress; oxidative stress ... See more keywords
The Role of NRF2 in Bone Metabolism – Friend or Foe?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.813057
Abstract: Bone metabolism is closely related to oxidative stress. As one of the core regulatory factors of oxidative stress, NRF2 itself and its regulation of oxidative stress are both involved in bone metabolism. NRF2 plays an… read more here.
Keywords: bone; nrf2 bone; bone metabolism; role nrf2 ... See more keywords
Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.720076
Abstract: Breast cancer is the second leading cancer among all types of cancers. It accounts for 12% of the total cases of cancers. The complex and heterogeneous nature of breast cancer makes it difficult to treat… read more here.
Keywords: breast cancer; nrf2 signaling; cancer; role nrf2 ... See more keywords
Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches – Pulmonary Disease/Asthma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.727806
Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a major transcription factor involved in redox homeostasis and in the response induced by oxidative injury. Nrf2 is present in an inactive state in the cytoplasm of… read more here.
Keywords: pulmonary disease; role nrf2; disease; oxidative stress ... See more keywords