An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02206-x
Abstract: While DNA methylation patterns have been studied for a role in the pathogenesis of anxiety disorders, the role of the enzymes establishing DNA methylation—DNA methyltransferases (DNMTs)—has yet to be investigated. In an effort to investigate… read more here.
Keywords: dna; anxiety; disorder; panic disorder ... See more keywords
Programmed Necroptosis is Upregulated in Low-grade Myelodysplastic Syndromes and May Play a Role in the Pathogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental hematology"
DOI: 10.1016/j.exphem.2021.09.004
Abstract: Myelodysplastic syndrome (MDS) is characterized by persistent cytopenias and evidence of morphologic dysplasia in the bone marrow (BM). Excessive hematopoietic programmed cell death (PCD) and inflammation have been demonstrated in MDS patients' bone marrow and… read more here.
Keywords: mds; role pathogenesis; low grade;
Is there a role for IL-17 in the pathogenesis of systemic sclerosis?
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.09.007
Abstract: In systemic sclerosis (SSc) immuno-inflammatory events are central to disease development. Amongst other mediators of inflammation, interleukin 17 (IL-17) and Th17 cells have been reported to be increased in the peripheral blood and target organs… read more here.
Keywords: sclerosis; ssc; pathogenesis systemic; production ... See more keywords
HERVs role in the pathogenesis, diagnosis or prognosis of aging diseases: A systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220525144135
Abstract: HERVs are humans endogenous retroviruses, which represent about 8% of human genome, and have various physiological functions, specially in pregnancy, embryo development and placenta formation. However, their involvement in diseases is not well defined. Some… read more here.
Keywords: diagnosis prognosis; role pathogenesis; systematic review;
PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH)
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11050792
Abstract: Simple Summary In the context of liver disease, one of the more growing public health problems is the transition from simple steatosis to non-alcoholic steatohepatitis. Profound metabolic dysregulations linked to inflammation and hepatic injury are… read more here.
Keywords: non alcoholic; ppar; alcoholic steatohepatitis; pathogenesis ... See more keywords