PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin
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DOI: 10.3390/ijms22084114
Abstract: Human atherosclerotic plaque contains smooth muscle cells (SMCs) negative for the contractile phenotype (α-smooth muscle actin) but positive for proprotein convertase subtilisin/kexin type 9 (PCSK9). Thus, we generated rat SMCs which overexpressed human PCSK9 (SMCsPCSK9)… read more here.
Keywords: role pcsk9; cell proliferation; proliferation; smooth muscle ... See more keywords
Insight into the Evolving Role of PCSK9
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12030256
Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells. This serine protease plays a pivotal role in the reduction of the… read more here.
Keywords: role pcsk9; proprotein; role; insight evolving ... See more keywords