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Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7702681
Abstract: The M2 isoform of pyruvate kinase (PKM2) is one isoform of pyruvate kinase (PK). PKM2 is expressed at high levels during embryonic development and tumor progression and is subject to complex allosteric regulation. PKM2 is…
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Keywords:
role pkm2;
pkm2;
mitochondrial function;
regulation ... See more keywords
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2
Published in 2022 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s366403
Abstract: Abstract Diabetic microangiopathy is among the most common complications affecting patients with diabetes, and includes both diabetic retinopathy (DR) and diabetic nephropathy (DKD). Diabetic microangiopathy remains a persistent threat to the health and quality of…
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Keywords:
role pkm2;
pkm2;
pkm2 diabetic;
diabetic microangiopathy ... See more keywords
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1
Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00159
Abstract: Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric,…
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Keywords:
kinase;
pyruvate kinase;
role pkm2;