The Role of PKM2 in the Regulation of Mitochondrial Function: Focus on Mitochondrial Metabolism, Oxidative Stress, Dynamic, and Apoptosis. PKM2 in Mitochondrial Function
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7702681
Abstract: The M2 isoform of pyruvate kinase (PKM2) is one isoform of pyruvate kinase (PK). PKM2 is expressed at high levels during embryonic development and tumor progression and is subject to complex allosteric regulation. PKM2 is… read more here.
Keywords: role pkm2; pkm2; mitochondrial function; regulation ... See more keywords
The Role of PKM2 in Diabetic Microangiopathy
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DOI: 10.2147/dmso.s366403
Abstract: Abstract Diabetic microangiopathy is among the most common complications affecting patients with diabetes, and includes both diabetic retinopathy (DR) and diabetic nephropathy (DKD). Diabetic microangiopathy remains a persistent threat to the health and quality of… read more here.
Keywords: role pkm2; pkm2; pkm2 diabetic; diabetic microangiopathy ... See more keywords
The Promising Role of PKM2 in the Diagnosis and Prognosis of Ovarian Cancer.
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DOI: 10.2174/0118715206394408250806065235
Abstract: PKM2 has emerged as a critical biomarker with the potential to enhance both diagnostic accuracy and therapeutic strategies in ovarian cancer. Due to its high fatality rate and difficulty identifying early signs, ovarian cancer remains… read more here.
Keywords: therapeutic strategies; cancer; ovarian cancer; role pkm2 ... See more keywords
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
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DOI: 10.3389/fonc.2020.00159
Abstract: Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. There are four isomeric,… read more here.
Keywords: kinase; pyruvate kinase; role pkm2;