The role of reversible and irreversible covalent chemistry in targeted protein degradation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.03.005
Abstract: Proteolysis-targeting chimeras (PROTACs) that degrade disease-causing proteins by hijacking the endogenous ubiquitin-proteasome system have emerged as an exciting and transformative technology in both chemical biology and drug discovery. Currently, the majority of PROTACs use reversible… read more here.
Keywords: chemistry; biology; irreversible covalent; role reversible ... See more keywords
The Role of Reversible Phosphorylation of Drosophila Rhodopsin
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314674
Abstract: Vertebrate and fly rhodopsins are prototypical GPCRs that have served for a long time as model systems for understanding GPCR signaling. Although all rhodopsins seem to become phosphorylated at their C-terminal region following activation by… read more here.
Keywords: role reversible; rhodopsin; reversible phosphorylation; phosphorylation ... See more keywords