Versatile role of sirtuins in metabolic disorders: From modulation of mitochondrial function to therapeutic interventions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23047
Abstract: Sirtuins (SIRT1–7) are distinct histone deacetylases (HDACs) whose activity is determined by cellular metabolic status andnicotinamide adenine dinucleotide (NAD+) levels. HDACs of class III are the members of the SIRT's protein family. SIRTs are the… read more here.
Keywords: role; role sirtuins; heart; versatile role ... See more keywords
Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13301
Abstract: The decline in bone mass and bone strength and musculoskeletal problems associated with aging constitute a major challenge for affected individuals and the healthcare system globally. Sirtuins 1‐7 (SIRT1‐SIRT7) are a family of nicotinamide adenine… read more here.
Keywords: sirtuins bone; bone; biology; role sirtuins ... See more keywords
Emerging Evidence concerning the Role of Sirtuins in Sepsis
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Research and Practice"
DOI: 10.1155/2018/5489571
Abstract: Sepsis, a dysregulated host response to infection, is a major public health concern. Though experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis is not completely understood. To date, numerous studies… read more here.
Keywords: sepsis; evidence concerning; concerning role; emerging evidence ... See more keywords
Role of Sirtuins in Tumor Angiogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01516
Abstract: Generally, changes in the metabolic status of cells under conditions like hypoxia and accumulation of lactate can be sensed by various sensing mechanisms, leading to modulation of a number of signal transduction pathways and transcription… read more here.
Keywords: sirtuins tumor; metabolic status; role; role sirtuins ... See more keywords
Role of Sirtuins in Physiology and Diseases of the Central Nervous System
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10102434
Abstract: Silent information regulators, sirtuins (SIRTs), are a family of enzymes which take part in major posttranslational modifications of proteins and contribute to multiple cellular processes, including metabolic and energetic transformations, as well as regulation of… read more here.
Keywords: role; central nervous; physiology; role sirtuins ... See more keywords
Role of Sirtuins in the Pathogenesis of Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021532
Abstract: Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease leading to joint destruction. The causes of RA are not fully known. Most likely, the development of the disease depends on the coexistence of many factors,… read more here.
Keywords: rheumatoid arthritis; rheumatoid; role sirtuins; sirtuins pathogenesis ... See more keywords
Role of sirtuins in esophageal cancer: Current status and future prospects
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastrointestinal Oncology"
DOI: 10.4251/wjgo.v14.i4.794
Abstract: Esophageal cancer (EC) is a malignant cancer that still has a poor prognosis, although its prognosis has been improving with the development of multidisciplinary treatment modalities such as surgery, chemotherapy and radiotherapy. Therefore, identifying specific… read more here.
Keywords: esophageal cancer; role; future prospects; sirtuins esophageal ... See more keywords